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Evaluation of elevated urinary enolase I levels in patients with endometriosis.

Authors
 Bo Hyon Yun  ;  You Sun Lee  ;  Seung Joo Chon  ;  Yeon Soo Jung  ;  Su Youn Yim  ;  Hye Yeon Kim  ;  Joo Hyun Park  ;  Seok Kyo Seo  ;  SiHyun Cho  ;  Young Sik Choi  ;  Byung Seok Lee 
Citation
 BIOMARKERS, Vol.19(1) : 16-21, 2014 
Journal Title
 BIOMARKERS 
ISSN
 1354-750X 
Issue Date
2014
MeSH
Adult ; Biomarkers/urine ; Biomarkers, Tumor/urine* ; CA-125 Antigen/blood ; Case-Control Studies ; Creatinine/urine ; DNA-Binding Proteins/urine* ; Endometriosis/diagnosis ; Endometriosis/enzymology ; Endometriosis/urine* ; Female ; Humans ; Phosphopyruvate Hydratase/urine* ; ROC Curve ; Tumor Suppressor Proteins/urine*
Keywords
Biomarker ; endometriosis ; enolase I ; urine
Abstract
OBJECTIVE: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis. METHODS: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine. RESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively. CONCLUSION: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis.
Full Text
http://informahealthcare.com/doi/abs/10.3109/1354750X.2013.863973
DOI
10.3109/1354750X.2013.863973
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Park, Joo Hyun(박주현)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Yim, Su Youn(임수연)
Chon, Seung Joo(전승주)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98096
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