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Efficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature

DC FieldValueLanguage
dc.contributor.author김호성-
dc.date.accessioned2015-01-06T16:25:51Z-
dc.date.available2015-01-06T16:25:51Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98091-
dc.description.abstractPURPOSE: It has been reported that daily recombinant human growth hormone (GH) treatment showed beneficial effects on growth in prepubertal children with idiopathic short stature (ISS). The present study aimed to validate the GH (Eutropin®) effect on growth promotion and safety after short-term GH treatment. MATERIALS AND METHODS: This study was an open-label, multicenter, interventional study conducted at nine university hospitals in Korea between 2008 and 2009. Thirty six prepubertal children with ISS were enrolled in this study to receive 6-month GH treatment. Yearly growth rate, height standard deviation score (SDS), and adverse events were investigated during treatment. RESULTS: After 26 weeks of GH treatment, the height velocity significantly increased by 6.36±3.36 cm/year (p<0.001). The lower end of one-sided 95% confidence interval was 5.22 cm/year, far greater than the predefined effect size. The gain in height SDS at week 26 was 0.57±0.27 (p<0.0001). Bone age significantly increased after GH treatment, however, bone maturation rate (bone age for chronological age) showed limited advancement. This 26-week GH treatment was effective in increasing serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 from baseline (p<0.0001). Eutropin was well tolerated and there were no withdrawals due to adverse events. No clinically significant changes in laboratory values were observed. CONCLUSION: This 6-month daily GH treatment in children with ISS demonstrated increased height velocity, improved height SDS, and increased IGF-I and IGFBP-3 levels with a favorable safety profile.-
dc.description.statementOfResponsibilityopen-
dc.format.extent53~60-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHGrowth Disorders/blood-
dc.subject.MESHGrowth Disorders/drug therapy*-
dc.subject.MESHGrowth Hormone/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHInsulin-Like Growth Factor Binding Protein 3/blood-
dc.subject.MESHInsulin-Like Growth Factor I/metabolism-
dc.subject.MESHMale-
dc.subject.MESHTreatment Outcome-
dc.titleEfficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorHo-Seong Kim-
dc.contributor.googleauthorSei Won Yang-
dc.contributor.googleauthorHan-Wook Yoo-
dc.contributor.googleauthorByung Kyu Suh-
dc.contributor.googleauthorCheol Woo Ko-
dc.contributor.googleauthorWoo Yeong Chung-
dc.contributor.googleauthorKee Hyoung Lee-
dc.contributor.googleauthorJin Soon Hwang-
dc.contributor.googleauthorHyi-Jeong Ji-
dc.contributor.googleauthorHyunji Ahn-
dc.contributor.googleauthorDuk Hee Kim-
dc.identifier.doi10.3349/ymj.2014.55.1.53-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01184-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339287-
dc.subject.keywordTreatment outcome-
dc.subject.keywordchild-
dc.subject.keywordgrowth hormone-
dc.subject.keywordidiopathic-
dc.subject.keywordsafety-
dc.subject.keywordshort stature-
dc.contributor.alternativeNameKim, Ho Seong-
dc.contributor.affiliatedAuthorKim, Ho Seong-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage53-
dc.citation.endPage60-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 53-60, 2014-
dc.identifier.rimsid54882-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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