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Analysis of HOX Gene Expression Patterns in Human Breast Cancer

 Ho Hur  ;  Ji-Yeon Lee  ;  Hyo Jung Yun  ;  Byeong Woo Park  ;  Myoung Hee Kim 
 MOLECULAR BIOTECHNOLOGY, Vol.56(1) : 64-71, 2014 
Journal Title
Issue Date
Breast Neoplasms/genetics* ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Homeobox* ; Homeodomain Proteins/genetics* ; Homeodomain Proteins/metabolism* ; Humans ; MCF-7 Cells ; Tumor Cells, Cultured ; Breast Neoplasms/genetics*
HOX ; Breast cancer ; Experssion analysis ; Cell lines ; Normal breast tissue ; Malignant breast tisse
HOX genes are highly conserved transcription factors that determine the identity of cells and tissues along the anterior–posterior body axis in developing embryos. Aberrations in HOX gene expression have been shown in various tumors. However, the correlation of HOX gene expression patterns with tumorigenesis and cancer progression has not been fully characterized. Here, to analyze putative candidate HOX genes involved in breast cancer tumorigenesis and progression, the expression patterns of 39 HOX genes were analyzed using breast cancer cell lines and patient-derived breast tissues. In vitro analysis revealed that HOXA and HOXB gene expression occurred in a subtype-specific manner in breast cancer cell lines, whereas most HOXC genes were strongly expressed in most cell lines. Among the 39 HOX genes analyzed, 25 were chosen for further analysis in malignant and non-malignant tissues. Fourteen genes, encoding HOXA6, A13, B2, B4, B5, B6, B7, B8, B9, C5, C9, C13, D1, and D8, out of 25 showed statistically significant differential expression patterns between non-malignant and malignant breast tissues and are putative candidates associated with the development and malignant progression of breast cancer. Our data provide a valuable resource for furthering our understanding of HOX gene expression in breast cancer and the possible involvement of HOX genes in tumor progression.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Lee, Ji Yeon(이지연) ORCID logo https://orcid.org/0000-0002-0670-3095
Hur, Ho(허호)
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