4 292

Cited 66 times in

YAP and TAZ Regulate Skin Wound Healing

Authors
 Min-Jung Lee  ;  Mi Ran Byun  ;  Makoto Furutani-Seiki  ;  Jeong-Ho Hong  ;  Han-Sung Jung 
Citation
 JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol.134(2) : 518-525, 2014 
Journal Title
 JOURNAL OF INVESTIGATIVE DERMATOLOGY 
ISSN
 0022-202X 
Issue Date
2014
MeSH
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism* ; Animals ; Dermis/injuries* ; Dermis/pathology ; Dermis/physiology ; Epidermis/injuries* ; Epidermis/pathology ; Epidermis/physiology ; Male ; Mice ; Mice, Inbred ICR ; NIH 3T3 Cells ; Phosphoproteins/genetics ; Phosphoproteins/metabolism* ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Small Interfering/genetics ; Signal Transduction/physiology ; Transcription Factors/genetics ; Transcription Factors/metabolism* ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Wound Healing/physiology*
Abstract
The Hippo signaling pathway regulates organ size, tissue regeneration, and stem cell self-renewal. The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological functions of the Hippo pathway. The biological functions of YAP and TAZ in many tissues are known; however, their roles in skin wound healing remain unclear. To analyze whether YAP and/or TAZ are required for cutaneous wound healing, we performed small interfering RNA (siRNA)–mediated knockdown of YAP/TAZ in full-thickness skin wounds. YAP is strongly expressed in the nucleus and cytoplasm in the epidermis and hair follicle. Interestingly, YAP is expressed in the nucleus in the dermis at 2 and 7 days after wounding. TAZ normally localizes to the cytoplasm in the dermis but is distributed in both the nucleus and cytoplasm at 1 day after wounding. The knockdown of YAP and TAZ markedly delayed the rate of wound closure and reduced the transforming growth factor-β1 (TGF-β1) expression in the wound. YAP and TAZ also modulate the expression of TGF-β1 signaling pathway components such as Smad-2, p21, and Smad-7. These results suggest that YAP and TAZ localization to the nucleus is required for skin wound healing.
Full Text
http://www.nature.com/jid/journal/v134/n2/full/jid2013339a.html
DOI
10.1038/jid.2013.339
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98040
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse