Cited 16 times in
High-Dose Etoposide Plus Granulocyte Colony-Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma Previously Treated with CHOP-based Chemotherapy: A Study from the Consortium for Improving Survival of Lymphoma
DC Field | Value | Language |
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dc.contributor.author | 김수정 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 현신영 | - |
dc.date.accessioned | 2015-01-06T16:23:44Z | - |
dc.date.available | 2015-01-06T16:23:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98024 | - |
dc.description.abstract | We conducted a multicenter retrospective study to compare the efficacy and toxicity of various chemomobilization regimens: high-dose (HD) cyclophosphamide, HD etoposide (VP-16), and platinum-based chemotherapies. We reviewed the experiences of 10 institutions with 103 non-Hodgkin lymphoma patients who had previously only been treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)-based chemotherapy. The mobilization yields for each regimen were analyzed. HD VP-16 mobilized a significantly higher median number of CD34+ cells (16.22 × 106 cells/kg) than HD cyclophosphamide (4.44 × 106 cells/kg) or platinum-based chemotherapies (6.08 × 106 cells/kg, P < .001). The rate of successful mobilization (CD34+ cell count ≥5.0 × 106 cells/kg) was also significantly higher for HD VP-16 (86%) than for HD cyclophosphamide (45%) or platinum-based chemotherapies (61%, P = .004). The successful mobilization rate on day 1 of 72% for HD VP-16 was significantly higher than the rates for HD cyclophosphamide (13%) and platinum-based chemotherapies (26%, P < .001). In multivariate analysis, HD VP-16 was a significant predictor of successful mobilization (P = .014; odds ratio, 5.25; 95% confidence interval, 1.40 to 19.63). Neutropenic fever occurred in 67% of patients treated with HD VP-16. The incidence was similar for HD cyclophosphamide (58%, P = .454) but was significantly lower for platinum-based chemotherapies (12%, P < .001). However, fatal (grade ≥ 4) infection and treatment-related mortality were not observed in this study. In conclusion, the mobilization yield was significantly influenced by the chemomobilization regimen, and HD VP-16 was a highly effective mobilization regimen in patients with non-Hodgkin lymphoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 73~79 | - |
dc.relation.isPartOf | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antigens, CD34/metabolism | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Cisplatin/pharmacology | - |
dc.subject.MESH | Cyclophosphamide/pharmacology | - |
dc.subject.MESH | Cyclophosphamide/therapeutic use | - |
dc.subject.MESH | Doxorubicin/therapeutic use | - |
dc.subject.MESH | Etoposide/pharmacology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Granulocyte Colony-Stimulating Factor/pharmacology* | - |
dc.subject.MESH | Hematopoietic Stem Cell Mobilization/methods* | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation* | - |
dc.subject.MESH | Hematopoietic Stem Cells/drug effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphoma, Non-Hodgkin/immunology | - |
dc.subject.MESH | Lymphoma, Non-Hodgkin/mortality | - |
dc.subject.MESH | Lymphoma, Non-Hodgkin/pathology | - |
dc.subject.MESH | Lymphoma, Non-Hodgkin/therapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prednisone/therapeutic use | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.subject.MESH | Vincristine/therapeutic use | - |
dc.title | High-Dose Etoposide Plus Granulocyte Colony-Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma Previously Treated with CHOP-based Chemotherapy: A Study from the Consortium for Improving Survival of Lymphoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Shin Young Hyun | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Soo-Jeong Kim | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.contributor.googleauthor | Deok-Hwan Yang | - |
dc.contributor.googleauthor | Jae-Sook Ahn | - |
dc.contributor.googleauthor | Won-Sik Lee | - |
dc.contributor.googleauthor | Hun-Mo Ryoo | - |
dc.contributor.googleauthor | Young Rok Do | - |
dc.contributor.googleauthor | Ho Sup Lee | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Sung Yong Oh | - |
dc.contributor.googleauthor | Cheolwon Suh | - |
dc.contributor.googleauthor | Ho-Young Yhim | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.identifier.doi | 10.1016/j.bbmt.2013.10.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A04381 | - |
dc.relation.journalcode | J00308 | - |
dc.identifier.eissn | 1523-6536 | - |
dc.identifier.pmid | 24141009 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1083879113004606 | - |
dc.subject.keyword | Cyclophosphamide | - |
dc.subject.keyword | Etoposide | - |
dc.subject.keyword | Non-Hodgkin lymphoma | - |
dc.subject.keyword | Platinum | - |
dc.subject.keyword | Stem cell mobilization | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Hyun, Shin Yong | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Hyun, Shin Yong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.20(1) : 73-79, 2014 | - |
dc.identifier.rimsid | 54338 | - |
dc.type.rims | ART | - |
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