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High-Dose Etoposide Plus Granulocyte Colony-Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma Previously Treated with CHOP-based Chemotherapy: A Study from the Consortium for Improving Survival of Lymphoma

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author정준원-
dc.contributor.author현신영-
dc.date.accessioned2015-01-06T16:23:44Z-
dc.date.available2015-01-06T16:23:44Z-
dc.date.issued2014-
dc.identifier.issn1083-8791-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98024-
dc.description.abstractWe conducted a multicenter retrospective study to compare the efficacy and toxicity of various chemomobilization regimens: high-dose (HD) cyclophosphamide, HD etoposide (VP-16), and platinum-based chemotherapies. We reviewed the experiences of 10 institutions with 103 non-Hodgkin lymphoma patients who had previously only been treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)-based chemotherapy. The mobilization yields for each regimen were analyzed. HD VP-16 mobilized a significantly higher median number of CD34+ cells (16.22 × 106 cells/kg) than HD cyclophosphamide (4.44 × 106 cells/kg) or platinum-based chemotherapies (6.08 × 106 cells/kg, P < .001). The rate of successful mobilization (CD34+ cell count ≥5.0 × 106 cells/kg) was also significantly higher for HD VP-16 (86%) than for HD cyclophosphamide (45%) or platinum-based chemotherapies (61%, P = .004). The successful mobilization rate on day 1 of 72% for HD VP-16 was significantly higher than the rates for HD cyclophosphamide (13%) and platinum-based chemotherapies (26%, P < .001). In multivariate analysis, HD VP-16 was a significant predictor of successful mobilization (P = .014; odds ratio, 5.25; 95% confidence interval, 1.40 to 19.63). Neutropenic fever occurred in 67% of patients treated with HD VP-16. The incidence was similar for HD cyclophosphamide (58%, P = .454) but was significantly lower for platinum-based chemotherapies (12%, P < .001). However, fatal (grade ≥ 4) infection and treatment-related mortality were not observed in this study. In conclusion, the mobilization yield was significantly influenced by the chemomobilization regimen, and HD VP-16 was a highly effective mobilization regimen in patients with non-Hodgkin lymphoma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent73~79-
dc.relation.isPartOfBIOLOGY OF BLOOD AND MARROW TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntigens, CD34/metabolism-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHCisplatin/pharmacology-
dc.subject.MESHCyclophosphamide/pharmacology-
dc.subject.MESHCyclophosphamide/therapeutic use-
dc.subject.MESHDoxorubicin/therapeutic use-
dc.subject.MESHEtoposide/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHGranulocyte Colony-Stimulating Factor/pharmacology*-
dc.subject.MESHHematopoietic Stem Cell Mobilization/methods*-
dc.subject.MESHHematopoietic Stem Cell Transplantation*-
dc.subject.MESHHematopoietic Stem Cells/drug effects*-
dc.subject.MESHHumans-
dc.subject.MESHLymphoma, Non-Hodgkin/immunology-
dc.subject.MESHLymphoma, Non-Hodgkin/mortality-
dc.subject.MESHLymphoma, Non-Hodgkin/pathology-
dc.subject.MESHLymphoma, Non-Hodgkin/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPrednisone/therapeutic use-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTransplantation, Autologous-
dc.subject.MESHVincristine/therapeutic use-
dc.titleHigh-Dose Etoposide Plus Granulocyte Colony-Stimulating Factor as an Effective Chemomobilization Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma Previously Treated with CHOP-based Chemotherapy: A Study from the Consortium for Improving Survival of Lymphoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorShin Young Hyun-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorDeok-Hwan Yang-
dc.contributor.googleauthorJae-Sook Ahn-
dc.contributor.googleauthorWon-Sik Lee-
dc.contributor.googleauthorHun-Mo Ryoo-
dc.contributor.googleauthorYoung Rok Do-
dc.contributor.googleauthorHo Sup Lee-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorSung Yong Oh-
dc.contributor.googleauthorCheolwon Suh-
dc.contributor.googleauthorHo-Young Yhim-
dc.contributor.googleauthorJin Seok Kim-
dc.identifier.doi10.1016/j.bbmt.2013.10.012-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00633-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA03729-
dc.contributor.localIdA04381-
dc.relation.journalcodeJ00308-
dc.identifier.eissn1523-6536-
dc.identifier.pmid24141009-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1083879113004606-
dc.subject.keywordCyclophosphamide-
dc.subject.keywordEtoposide-
dc.subject.keywordNon-Hodgkin lymphoma-
dc.subject.keywordPlatinum-
dc.subject.keywordStem cell mobilization-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.alternativeNameHyun, Shin Yong-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.contributor.affiliatedAuthorHyun, Shin Yong-
dc.rights.accessRightsfree-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPage73-
dc.citation.endPage79-
dc.identifier.bibliographicCitationBIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.20(1) : 73-79, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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