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Clinical Outcomes and Prognostic Factors of Empirical Antifungal Therapy with Itraconazole in the Patients with Hematological Malignancies: A Prospective Multicenter Observational Study in Korea

DC FieldValueLanguage
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author정준원-
dc.date.accessioned2015-01-06T16:23:42Z-
dc.date.available2015-01-06T16:23:42Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98023-
dc.description.abstractPURPOSE: To identify prognostic factors for the outcomes of empirical antifungal therapy, we performed a multicenter, prospective, observational study in immunocompromised patients with hematological malignancies. MATERIALS AND METHODS: Three hundred seventy-six patients (median age of 48) who had neutropenic fever and who received intravenous (IV) itraconazole as an empirical antifungal therapy for 3 or more days were analyzed. The patients with possible or probable categories of invasive fungal disease (IFD) were enrolled. RESULTS: The overall success rate was 51.3% (196/376). Age >50 years, underlying lung disease (co-morbidity), poor performance status [Eastern Cooperative Oncology Group (ECOG) ≥2], radiologic evidence of IFD, longer duration of baseline neutropenic fever (≥4 days), no antifungal prophylaxis or prophylactic use of antifungal agents other than itraconazole, and high tumor burden were associated with decreased success rate in univariate analysis. In multivariate analysis, age >50 years (p=0.009) and poor ECOG performance status (p=0.005) were significantly associated with poor outcomes of empirical antifungal therapy. Twenty-two patients (5.9%) discontinued itraconazole therapy due to toxicity. CONCLUSION: We concluded that empirical antifungal therapy with IV itraconazole in immunocompromised patients is effective and safe. Additionally, age over 50 years and poor performance status were poor prognostic factors for the outcomes of empirical antifungal therapy with IV itraconazole.-
dc.description.statementOfResponsibilityopen-
dc.format.extent9~18-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntifungal Agents/adverse effects-
dc.subject.MESHAntifungal Agents/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHematologic Neoplasms-
dc.subject.MESHHumans-
dc.subject.MESHImmunocompromised Host-
dc.subject.MESHItraconazole/adverse effects-
dc.subject.MESHItraconazole/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.titleClinical Outcomes and Prognostic Factors of Empirical Antifungal Therapy with Itraconazole in the Patients with Hematological Malignancies: A Prospective Multicenter Observational Study in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorHo Jin Shin-
dc.contributor.googleauthorJong Wook Lee-
dc.contributor.googleauthorJe-Hwan Lee-
dc.contributor.googleauthorDeok-Hwan Yang-
dc.contributor.googleauthorWon Sik Lee-
dc.contributor.googleauthorHawk Kim-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorSung-Hyun Kim-
dc.contributor.googleauthorYang Soo Kim-
dc.contributor.googleauthorJae-Yong Kwak-
dc.contributor.googleauthorYee Soo Chae-
dc.contributor.googleauthorJinny Park-
dc.contributor.googleauthorYoung Rok Do-
dc.contributor.googleauthorYoo Hong Min-
dc.identifier.doi10.3349/ymj.2014.55.1.9-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA03729-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339281-
dc.subject.keywordHematological malignancy-
dc.subject.keywordempirical antifungal therapy-
dc.subject.keyworditraconazole-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage9-
dc.citation.endPage18-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 9-18, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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