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Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery

DC Field Value Language
dc.contributor.author길혜금-
dc.contributor.author김나영-
dc.contributor.author김소연-
dc.date.accessioned2015-01-06T16:22:13Z-
dc.date.available2015-01-06T16:22:13Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97980-
dc.description.abstractPURPOSE: Dexmedetomidine, a potent selective α2-adrenergic agonist, produces sedation and analgesia. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements, recovery profiles, and emergence agitation in children undergoing ambulatory surgery. MATERIALS AND METHODS: Forty children undergoing ambulatory hernioplasty or orchiopexy were randomized into two groups. The dexmedetomidine group (Group D, n=20) received dexmedetomidine 1 μg/kg, followed by 0.1 μg/kg/h until the end of surgery, whereas the saline group (Group S, n=20) received volume-matched normal saline. Sevoflurane was used for induction and maintenance of anesthesia and caudal block was performed in all children. End-tidal sevoflurane concentration (ET-sevo), the incidence of emergence agitation, pain scores, and sedation scores were recorded. Hemodynamic changes and other adverse effects were assessed in the perioperative period. RESULTS: ET-sevo of Group D was significantly reduced in 23.8-67% compared to Group S during surgery. The incidence of emergence agitation was lower in Group D than in Group S (5% vs. 55%, p=0.001). Postoperative pain was comparable, and discharge time was not different between the groups. Mean arterial pressure and heart rate were significantly lower in Group D during surgery. CONCLUSION: Intraoperative infusion of dexmedetomidine reduced sevoflurane requirements and decreased emergence agitation without delaying discharge in children undergoing ambulatory surgery. However, caution should be taken in regard to bradycardia and hypotension.-
dc.description.statementOfResponsibilityopen-
dc.format.extent209~215-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAmbulatory Surgical Procedures/methods*-
dc.subject.MESHChild-
dc.subject.MESHDexmedetomidine/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHemodynamics/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMethyl Ethers/therapeutic use*-
dc.subject.MESHPsychomotor Agitation/drug therapy-
dc.subject.MESHYoung Adult-
dc.titleEffect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorHye Jin Yoon-
dc.contributor.googleauthorHae Keum Kil-
dc.identifier.doi10.3349/ymj.2014.55.1.209-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00283-
dc.contributor.localIdA00616-
dc.contributor.localIdA00348-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339309-
dc.subject.keywordAgitation-
dc.subject.keywordambulatory surgery-
dc.subject.keyworddexmedetomidine-
dc.subject.keywordemergence-
dc.subject.keywordsevoflurane-
dc.contributor.alternativeNameKil, Hae Keum-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.affiliatedAuthorKil, Hae Keum-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorKim, Na Young-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage209-
dc.citation.endPage215-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 209-215, 2014-
dc.identifier.rimsid53465-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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