Cited 6 times in
Metabolic phenotypes in primary unknown metastatic carcinoma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 김혜민 | - |
dc.date.accessioned | 2015-01-06T16:21:53Z | - |
dc.date.available | 2015-01-06T16:21:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97970 | - |
dc.description.abstract | BACKGROUND: The purpose of this study is to evaluate expression of metabolism-related proteins in primary unknown metastatic carcinoma (PUMC) and associated implications for treatment. METHODS: A tissue microarray containing 77 cases of PUMC was constructed and immunohistochemical staining was used to evaluate expression of the following proteins: Glycolysis-related: Glut-1, carbonic anhydrase (CA) IX, and monocarboxylate transporter (MCT) 4; Glutaminolysis-related: glutaminase1 (GLS1), glutamate dehydrogenase (GDH), and amino acid transporter-2 (ASCT2); and Mitochondrial-related: ATP synthase, succinate dehydrogenase (SDH)A, and SDHB. The association between immunohistochemical staining results and clinicopathologic parameters was evaluated. RESULTS: The expression of metabolism-related proteins was different depending on the histologic subtype. Compared to other subtypes, squamous cell carcinomas (SQ) expressed more Glut-1 (p = 0.028), while adenocarcinomas (AD) expressed more SDHB in the stroma (p = 0.025). The expression of metabolism-related proteins was also different depending on the clinical subtypes. Glut-1 was expressed most in the nodal type and the least in carcinomatosis type, when compared to other subtypes (p = 0.021). The metabolic phenotypes also showed other trends: when the stroma showed no glutaminolysis, the tumor mostly invaded lymph node, bone, and brain, while the tumor invaded regions other than lymph node, bone, and brain when the stroma showed glutaminolysis (p = 0.003). When the stroma showed the mitochondrial metabolic type, the histologic subtype was mainly AD, but the non-mitochondrial type was associated more with SQ (P = 0.049). CONCLUSION: For PUMC, the expression of metabolism-related proteins, such as Glut-1 and SDHB, differs in the tumor or stroma depending on the clinical and histologic tumor subtype. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose Transporter Type 1/metabolism | - |
dc.subject.MESH | Glycolysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitochondrial Proteins/metabolism | - |
dc.subject.MESH | Neoplasm Metastasis/pathology* | - |
dc.subject.MESH | Neoplasm Proteins/metabolism | - |
dc.subject.MESH | Neoplasms, Unknown Primary/classification | - |
dc.subject.MESH | Neoplasms, Unknown Primary/metabolism* | - |
dc.subject.MESH | Neoplasms, Unknown Primary/pathology* | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Stromal Cells/metabolism | - |
dc.subject.MESH | Stromal Cells/pathology | - |
dc.subject.MESH | Succinate Dehydrogenase/metabolism | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Metabolic phenotypes in primary unknown metastatic carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1186/1479-5876-12-2 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01915 | - |
dc.identifier.eissn | 1479-5876 | - |
dc.identifier.pmid | 24387319 | - |
dc.identifier.url | http://www.translational-medicine.com/content/12/1/2 | - |
dc.subject.keyword | Carcinoma | - |
dc.subject.keyword | Primary unknown | - |
dc.subject.keyword | Metabolism | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TRANSLATIONAL MEDICINE, Vol.12(2) : 1-13, 2014 | - |
dc.identifier.rimsid | 53458 | - |
dc.type.rims | ART | - |
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