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Feasibility and Outcomes of Hypofractionated Simultaneous Integrated Boost-Intensity Modulated Radiotherapy for Malignant Gliomas: A Preliminary Report

DC FieldValueLanguage
dc.contributor.author김세훈-
dc.contributor.author김준원-
dc.contributor.author박광우-
dc.contributor.author서양권-
dc.contributor.author서창옥-
dc.contributor.author이규성-
dc.contributor.author장종희-
dc.contributor.author조재호-
dc.contributor.author차지혜-
dc.contributor.author장지석-
dc.date.accessioned2015-01-06T16:21:38Z-
dc.date.available2015-01-06T16:21:38Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97962-
dc.description.abstractPURPOSE: The aim of this study was to assess the feasibility and efficacy of hypofractionated simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) using three-layered planning target volumes (PTV) for malignant gliomas. MATERIALS AND METHODS: We conducted a retrospective analysis of 12 patients (WHO grade IV-10; III-2) postoperatively treated with SIB-IMRT with concurrent temozolomide. Three-layered PTVs were contoured based on gadolinium-enhanced magnetic resonance imaging as follows; high risk PTV (H-PTV) as the area of surgical bed including residual gross tumor with a 0.5 cm margin; low risk PTV (L-PTV) as the area surrounding the high risk PTV with 1.5 cm margin; moderate risk PTV (M-PTV) as a line at one-third the distance from high risk PTV to low risk PTV. Total dose to high risk PTV was 70 Gy in 8 and 62.5 Gy in 4 patients. RESULTS: The median follow-up time was 52 months in surviving patients. The 2- and 5-year overall survival (OS) rates were 66.6% and 47.6%, respectively. The 2- and 5-year progression-free survival (PFS) rates were 57.1% and 45.7%, respectively. The median OS and PFS were 48 and 31 months, respectively. Six patients (50%) progressed: in-field only in one, out-field or disseminated in 4, and both in one patient. All patients completed planned treatments without a toxicity-related gap. Asymptomatic radiation necrosis was observed in 4 patients at post-radiotherapy 9-31 months. CONCLUSION: An escalated dose of hypofractionated SIB-IMRT using three-layered PTVs can be safely performed in patients with malignant glioma, and might contribute to better tumor control and survival.-
dc.description.statementOfResponsibilityopen-
dc.format.extent70~77-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHGlioma/radiotherapy*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadiotherapy, Intensity-Modulated/methods*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHYoung Adult-
dc.titleFeasibility and Outcomes of Hypofractionated Simultaneous Integrated Boost-Intensity Modulated Radiotherapy for Malignant Gliomas: A Preliminary Report-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학)-
dc.contributor.googleauthorJihye Cha-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorKwangwoo Park-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorKyu Sung Lee-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorJoo Ho Kim-
dc.contributor.googleauthorYang-Gun Suh-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorJaeho Cho-
dc.identifier.doi10.3349/ymj.2014.55.1.70-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00610-
dc.contributor.localIdA00958-
dc.contributor.localIdA01432-
dc.contributor.localIdA01891-
dc.contributor.localIdA01919-
dc.contributor.localIdA03470-
dc.contributor.localIdA04009-
dc.contributor.localIdA02682-
dc.contributor.localIdA03901-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24339289-
dc.subject.keywordRadiotherapy-
dc.subject.keywordhypofractionation-
dc.subject.keywordintensity-modulated-
dc.subject.keywordmalignant glioma-
dc.subject.keywordsimultaneous integrated boost-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.alternativeNamePark, Kwang Woo-
dc.contributor.alternativeNameSuh, Yang Gun-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Kyu Sung-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.alternativeNameCha, Ji Hye-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Jun Won-
dc.contributor.affiliatedAuthorPark, Kwang Woo-
dc.contributor.affiliatedAuthorSuh, Yang Gun-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorCha, Ji Hye-
dc.contributor.affiliatedAuthorLee, Kyu Sung-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage70-
dc.citation.endPage77-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(1) : 70-77, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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