Cited 70 times in
Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment
DC Field | Value | Language |
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dc.contributor.author | 김창수 | - |
dc.date.accessioned | 2015-01-06T16:21:20Z | - |
dc.date.available | 2015-01-06T16:21:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97953 | - |
dc.description.abstract | Cerebrovascular disease (CVD) and amyloid burden are the most frequent pathologies in subjects with cognitive impairment. However, the relationship between CVD, amyloid burden, and cognition are largely unknown. We aimed to evaluate whether CVD (lacunes, white matter hyperintensities, and microbleeds) and amyloid burden (Pittsburgh compound B [PiB] retention ratio) contribute to cognitive impairment independently or interactively. We recruited 136 patients with subcortical vascular cognitive impairment who underwent magnetic resonance imaging, PiB–positron emission tomography, and neuropsychological testing. The number of lacunes was associated with memory, frontal dysfunctions, and disease severity. The volume of white matter hyperintensities and the PiB retention ratio were associated only with memory dysfunction. There was no direct correlation between CVD markers and PiB retention ratio except that the number of lacunes was negatively correlated with the PiB retention ratio. In addition, there were no interactive effects of CVD and PiB retention ratio on cognition. Our findings suggest that CVD and amyloid burden contribute independently and not interactively to specific patterns of cognitive dysfunction in patients with subcortical vascular cognitive impairment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 254~260 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Amyloid beta-Peptides/metabolism* | - |
dc.subject.MESH | Aniline Compounds | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Cerebrovascular Disorders/complications* | - |
dc.subject.MESH | Cognition Disorders/diagnosis | - |
dc.subject.MESH | Cognition Disorders/etiology* | - |
dc.subject.MESH | Cognition Disorders/metabolism | - |
dc.subject.MESH | Cognition Disorders/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Memory Disorders/diagnosis | - |
dc.subject.MESH | Memory Disorders/etiology | - |
dc.subject.MESH | Memory Disorders/pathology | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Thiazoles | - |
dc.title | Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | Jae-Hyun Park | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Sook Hui Kim | - |
dc.contributor.googleauthor | Geon Ha Kim | - |
dc.contributor.googleauthor | Sung Tae Kim | - |
dc.contributor.googleauthor | Seun Jeon | - |
dc.contributor.googleauthor | Jong Min Lee | - |
dc.contributor.googleauthor | Seung Jun Oh | - |
dc.contributor.googleauthor | Jae Seung Kim | - |
dc.contributor.googleauthor | Yearn Seong Choe | - |
dc.contributor.googleauthor | Kyung-Han Lee | - |
dc.contributor.googleauthor | Ji Soo Shin | - |
dc.contributor.googleauthor | Chi Hun Kim | - |
dc.contributor.googleauthor | Young Noh | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Cindy W. Yoon | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.contributor.googleauthor | Michael Ewers | - |
dc.contributor.googleauthor | Michael W. Weiner | - |
dc.contributor.googleauthor | Jae-Hong Lee | - |
dc.contributor.googleauthor | David J. Werring | - |
dc.contributor.googleauthor | Duk L. Na | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2013.06.026 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01042 | - |
dc.relation.journalcode | J02322 | - |
dc.identifier.eissn | 1558-1497 | - |
dc.identifier.pmid | 23932881 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S019745801300287X | - |
dc.subject.keyword | Amyloid | - |
dc.subject.keyword | Cerebrovascular disease | - |
dc.subject.keyword | Cognition | - |
dc.subject.keyword | Lacune | - |
dc.subject.keyword | Microbleed | - |
dc.subject.keyword | Pittsburgh compound B | - |
dc.subject.keyword | White matter hyperintensity | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | Kim, Chang Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 254 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, Vol.35(1) : 254-260, 2014 | - |
dc.identifier.rimsid | 53449 | - |
dc.type.rims | ART | - |
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