4 297

Cited 54 times in

Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer

Authors
 Sun-Mi Lee  ;  Hyung Joon Kim  ;  Sook Young Kim  ;  Min-Kyung Kwon  ;  Sol Kim  ;  Arthur Cho  ;  Mijin Yun  ;  Jeon-Soo Shin  ;  Kyung-Hwa Yoo 
Citation
 BIOMATERIALS, Vol.35(7) : 2272-2282, 2014 
Journal Title
 BIOMATERIALS 
ISSN
 0142-9612 
Issue Date
2014
MeSH
Animals ; Colonic Neoplasms/drug therapy* ; Drug Carriers* ; Drug Resistance, Neoplasm* ; Gold/chemistry* ; Humans ; Metal Nanoparticles* ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays
Keywords
Chemo-photothermal treatment ; Multidrug resistance ; Multifunctional nanoparticle ; Near infrared resonance ; Photothermally controlled drug delivery
Abstract
To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted in vitro and in vivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic-co-glycolic acid)–Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10 min, which caused an increase in temperature to 45 °C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemo-photothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors.
Full Text
http://www.sciencedirect.com/science/article/pii/S0142961213014348
DOI
10.1016/j.biomaterials.2013.11.068
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sook Young(김숙영)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97944
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse