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신장 허혈 재관류 손상에 미치는 Ethyl Pyruvate의 효과
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 이우정 | - |
dc.date.accessioned | 2014-12-21T17:30:50Z | - |
dc.date.available | 2014-12-21T17:30:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-0053 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97733 | - |
dc.description.abstract | Purpose: Reactive oxygen species (ROS) significantly contribute to ischemia-reperfusion injury, and are also associated with the gradual loss of renal function and renal failure following renal transplantation. Pyruvate is an endogenous antioxidant, but its use as a therapeutic agent for treating conditions mediated by oxidative stress is limited due to its poor stability in solution. However, ethyl pyruvate (EP), a soluble pyruvate derivative, has far greater stability than pyruvate; thus, may serve as a practical pyruvate precursor. Therefore, the ability of EP in the prevention of renal ischemia-reperfusion injury was assessed. Methods: Sprague-Dawley rats (n=54) were subjected to 40 minutes of renal warm ischemia. The animals were divided into three groups: the sham group without warm ischemia (n=18), the EP group (n=18, EP given before ischemia), and the ischemic control (n=18). The serum levels of creatinine and TNF-α were measured 1, 3 and 5 days after induction of ischemia. The expression of high mobility group box-1 (HMGB-1), a delayed inflammatory mediator, was also assessed by Western blot of renal specimens. Results: In the EP group, late improvements in the serum levels of creatinine and TNF-α were observed in comparison with the ischemic control. Based on this delayed effect, the expression of HMGB-1 was assessed in renal tissue. The HMGB-1 expression increased over time during the ischemia process, but EP suppressed this expression 3 and 5 days after renal ischemia-reperfusion injury. Conclusion: These results have demonstrated, for the first time, that EP ameliorates renal ischemia-reperfusion injury. EP attenuates the renal ischemia-reperfusion injury, at least in part, by suppressing the expression of HMGB-1, a late mediator of delayed inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 345~350 | - |
dc.publisher | 대한외과학회 | - |
dc.relation.isPartOf | JOURNAL OF THE KOREAN SURGICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 신장 허혈 재관류 손상에 미치는 Ethyl Pyruvate의 효과 | - |
dc.title.alternative | Ethyl Pyruvate Ameliorates Renal Ischemia- reperfusion Injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 정구용 | - |
dc.contributor.googleauthor | 정규영 | - |
dc.contributor.googleauthor | 김유선 | - |
dc.contributor.googleauthor | 한평림 | - |
dc.contributor.googleauthor | 이우정 | - |
dc.contributor.googleauthor | 장혜경 | - |
dc.contributor.googleauthor | 주만기 | - |
dc.contributor.googleauthor | 안형준 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00785 | - |
dc.relation.journalcode | J01893 | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 345 | - |
dc.citation.endPage | 350 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.72(5) : 345-350, 2007 | - |
dc.identifier.rimsid | 47672 | - |
dc.type.rims | ART | - |
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