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The Association of the Activation-Inducible Tumor Necrosis Factor Receptor and Ligand with Lumbar Disc Herniation

DC FieldValueLanguage
dc.contributor.author문성환-
dc.contributor.author이환모-
dc.contributor.author한수봉-
dc.date.accessioned2014-12-21T17:25:06Z-
dc.date.available2014-12-21T17:25:06Z-
dc.date.issued2007-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97553-
dc.description.abstractPURPOSE: Herniated nucleus pulposus fragments are recognized by the immune system as a foreign-body, which results in an autoimmune reaction. Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the pathogenesis of autoimmune diseases. Despite the importance of these costimulatory molecules in autoimmune disease, their role in the autoimmune reaction to herniated disc fragments has yet to be explored. The purpose of the present study is to investigate whether the overexpression of AITR and AITRL might be associated with lumbar disc herniation. MATERIALS AND METHODS: The study population consisted of 20 symptomatic lumbar disc herniation patients. Ten macroscopically normal control discs were obtained from patients with spinal fractures managed with anterior procedures that involved a discectomy. Peripheral blood samples from both the study patients and controls were collected. The expression levels of AITR and AITRL were investigated by flow cytometric analysis, confocal laser scanning microscopy, immunohistochemistry and by reverse transcriptase-polymerase chain reaction (RT-PCR). The soluble AITR and AITRL serum levels were measured by an enzyme-linked immunosorbent assay. RESULTS: Flow cytometric analysis revealed significantly higher levels of both AITR and AITRL in the lumbar disc herniation patients than in the controls. The AITRL expression levels were also increased in patients with lumbar disc herniation, shown by using confocal laser scanning microscopy, immunohisto-chemistry, and RT-PCR. Finally, soluble AITR and AITRL were elevated in the patients with lumbar disc herniations. CONCLUSION: The AITR and AITRL are increased in both the herniated disc tissue and the peripheral blood of patients with lumbar disc herniation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent839~846-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe Association of the Activation-Inducible Tumor Necrosis Factor Receptor and Ligand with Lumbar Disc Herniation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorMoon-Soo Park-
dc.contributor.googleauthorHwan-Mo Lee-
dc.contributor.googleauthorK. Daniel Riew-
dc.contributor.googleauthorByoung-Se Kwon-
dc.contributor.googleauthorHyo-Won Jung-
dc.contributor.googleauthorChoon-Sung Lee-
dc.contributor.googleauthorYung-Tae Kim-
dc.contributor.googleauthorSeong-Hwan Moon-
dc.contributor.googleauthorSoo-Bong Hahn-
dc.identifier.doi10.3349/ymj.2007.48.5.839-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01365-
dc.contributor.localIdA03333-
dc.contributor.localIdA04293-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.contributor.alternativeNameMoon, Seong Hwan-
dc.contributor.alternativeNameLee, Hwan Mo-
dc.contributor.alternativeNameHahn, Soo Bong-
dc.contributor.affiliatedAuthorMoon, Seong Hwan-
dc.contributor.affiliatedAuthorLee, Hwan Mo-
dc.contributor.affiliatedAuthorHahn, Soo Bong-
dc.rights.accessRightsfree-
dc.citation.volume48-
dc.citation.number5-
dc.citation.startPage839-
dc.citation.endPage846-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.48(5) : 839-846, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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