Cited 40 times in
Serum Amyloid A as a Useful Indicator of Disease Activity in Patients with Ankylosing Spondylitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박민찬 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 이수곤 | - |
dc.contributor.author | 정상윤 | - |
dc.date.accessioned | 2014-12-21T17:23:57Z | - |
dc.date.available | 2014-12-21T17:23:57Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97516 | - |
dc.description.abstract | PURPOSE: To investigate whether serum amyloid A (SAA) levels are increased in patients with ankylosing spondylitis (AS) and whether its levels correlate well with AS disease activity. MATERIALS AND METHODS: Thirty-eight patients with AS and 38 age- and sex-matched control subjects were enrolled in this cross-sectional study. Their SAA levels were quantitatively measured by immunonephelometry. An established, self-administered instrument for evaluating disease activity (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI) was used to measure and acute phase reactants, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), in patients with AS. RESULTS: Patients with AS had a significantly higher mean SAA level than controls (9.52 +/- 7.49mg/L versus 2.73 +/- 1.57mg/L, p < 0.05), and the mean BASDAI score of patients with elevated SAA levels was significantly higher than that of patients with normal SAA levels (5.6 +/- 1.3 versus 4.4 +/- 1.5, p < 0.05). SAA levels showed significant correlations with BASDAI scores (r=0.431, p=0.007), ESR (r=0.521, p=0.001) and CRP levels (r=0.648, p < 0.001). Additionally, the correlation between ESR and CRP levels also appeared significant (r=0.703, p < 0.001). In those with normal ESR or CRP levels, SAA levels and BASDAI scores were elevated (p < 0.05) and showed a trend of positive correlation with one another. CONCLUSION: Our data showed that SAA levels were increased in patients with AS and correlated well with disease activity. These findings suggest that SAA can be used as a valuable indicator of disease activity in AS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 218~224 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Serum Amyloid A as a Useful Indicator of Disease Activity in Patients with Ankylosing Spondylitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Youn Jung | - |
dc.contributor.googleauthor | Min-Chan Park | - |
dc.contributor.googleauthor | Soo-Kon Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.identifier.doi | 10.3349/ymj.2007.48.2.218 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01470 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02889 | - |
dc.contributor.localId | A03613 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.contributor.alternativeName | Park, Min Chan | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.alternativeName | Jung, Sang Youn | - |
dc.contributor.affiliatedAuthor | Park, Min Chan | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Jung, Sang Youn | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 218 | - |
dc.citation.endPage | 224 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.48(2) : 218-224, 2007 | - |
dc.identifier.rimsid | 57416 | - |
dc.type.rims | ART | - |
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