1 194

Cited 51 times in

HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet’s disease

DC FieldValueLanguage
dc.contributor.author방동식-
dc.date.accessioned2014-12-21T17:20:19Z-
dc.date.available2014-12-21T17:20:19Z-
dc.date.issued2007-
dc.identifier.issn0001-2815-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97401-
dc.description.abstractThe nonclassical human leukocyte antigen (HLA)-E and -G molecules have previously been shown to inhibit natural killer- and cytotoxic T-lymphocyte-mediated cell lysis and have also been shown to prevent the proliferation of CD4 T cells and secrete cytokines that appear to be important in the modulation of the Behcet’s disease (BD) immune systems. Polymorphisms in the HLA-E and HLA-G genes have been associated with differential expression and function. Thus, we conducted an analysis of the HLA-E and HLA-G alleles using Amplification Refractory Mutation System-polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism techniques in a study comprising 312 patients with BD and 486 controls. The HLA-E*0101 and HLA-G*010101 alleles were associated with a reduced risk of BD (P = 0.0002, odds ratio (OR) = 0.7 and P = 0.002, OR = 0.7, respectively). By way of contrast, the variants HLA-E*010302, HLA-G*010102, G*0105N alleles and 3741_3754ins14bp were all associated with an increased risk of BD (P < 0.0001, OR = 1.6; P = 0.002, OR = 1.8; P = 0.024, OR = 2.0 and P = 0.003, OR = 1.4, respectively). Individuals carrying both the HLA-E*0101 and the HLA-G*010101 alleles evidenced significantly lower frequency in the patients than in the controls (35.6% vs 49.6%; P < 0.0001, OR = 0.6). These results indicate that variant HLA-E and HLA-G molecules appear to function independently and synergistically, increasing the risk of BD, and may result in an imbalance of lymphocytic functions, which may culminate in the development of BD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent139~144-
dc.relation.isPartOfTISSUE ANTIGENS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHLA-E*0101 and HLA-G*010101 reduce the risk of Behcet’s disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학)-
dc.contributor.googleauthorK. S. Park-
dc.contributor.googleauthorJ. S. Park-
dc.contributor.googleauthorE. S. Lee-
dc.contributor.googleauthorS. Sohn-
dc.contributor.googleauthorD. Bang-
dc.contributor.googleauthorJ. H. Nam-
dc.identifier.doi10.1111/j.1399-0039.2006.00742.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01784-
dc.relation.journalcodeJ02731-
dc.identifier.eissn1399-0039-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1399-0039.2006.00742.x/abstract-
dc.contributor.alternativeNameBang, Dong Sik-
dc.contributor.affiliatedAuthorBang, Dong Sik-
dc.rights.accessRightsnot free-
dc.citation.volume69-
dc.citation.number2-
dc.citation.startPage139-
dc.citation.endPage144-
dc.identifier.bibliographicCitationTISSUE ANTIGENS , Vol.69(2) : 139-144, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.