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Differential Antigen Processing by Dendritic Cell Subsets in Vivo

DC FieldValueLanguage
dc.contributor.author박채규-
dc.date.accessioned2014-12-21T17:18:52Z-
dc.date.available2014-12-21T17:18:52Z-
dc.date.issued2007-
dc.identifier.issn0036-8075-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97355-
dc.description.abstractDendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8– DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.-
dc.description.statementOfResponsibilityopen-
dc.format.extent107~111-
dc.relation.isPartOfSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDifferential Antigen Processing by Dendritic Cell Subsets in Vivo-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorDiana Dudziak-
dc.contributor.googleauthorAlice O. Kamphorst-
dc.contributor.googleauthorMichel C. Nussenzweig-
dc.contributor.googleauthorRalph M. Steinman-
dc.contributor.googleauthorChae Gyu Park-
dc.contributor.googleauthorHan-Woong Lee-
dc.contributor.googleauthorKang Liu-
dc.contributor.googleauthorCheolho Cheong-
dc.contributor.googleauthorSayuri Yamazaki-
dc.contributor.googleauthorChristine Trumpfheller-
dc.contributor.googleauthorVeit R. Buchholz-
dc.contributor.googleauthorGordon F. Heidkamp-
dc.identifier.doi10.1126/science.1136080-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01718-
dc.relation.journalcodeJ02642-
dc.identifier.eissn1095-9203-
dc.contributor.alternativeNamePark, Chae Gyu-
dc.contributor.affiliatedAuthorPark, Chae Gyu-
dc.rights.accessRightsfree-
dc.citation.volume315-
dc.citation.number5808-
dc.citation.startPage107-
dc.citation.endPage111-
dc.identifier.bibliographicCitationSCIENCE, Vol.315(5808) : 107-111, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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