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Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Authors
 Diana Dudziak  ;  Alice O. Kamphorst  ;  Michel C. Nussenzweig  ;  Ralph M. Steinman  ;  Chae Gyu Park  ;  Han-Woong Lee  ;  Kang Liu  ;  Cheolho Cheong  ;  Sayuri Yamazaki  ;  Christine Trumpfheller  ;  Veit R. Buchholz  ;  Gordon F. Heidkamp 
Citation
 SCIENCE, Vol.315(5808) : 107-111, 2007 
Journal Title
 SCIENCE 
ISSN
 0036-8075 
Issue Date
2007
Abstract
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies. Unlike CD8+ DCs that express the cell surface protein CD205, CD8– DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II. This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing.
Files in This Item:
T200703847.pdf Download
DOI
10.1126/science.1136080
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Chae Gyu(박채규) ORCID logo https://orcid.org/0000-0003-1906-1308
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97355
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