Cited 22 times in
Calcium-Calmodulin Mediates House Dust Mite-Induced ERK Activation and IL-8 Production in Human Respiratory Epithelial Cells
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김은수 | - |
dc.contributor.author | 박준영 | - |
dc.contributor.author | 손명현 | - |
dc.date.accessioned | 2014-12-21T17:18:33Z | - |
dc.date.available | 2014-12-21T17:18:33Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97345 | - |
dc.description.abstract | BACKGROUND: House dust mites (HDM) have been shown to be important sources of indoor allergens associated with asthma and other allergic conditions. While exogenous proteases from allergens have a direct proinflammatory role in the respiratory tract, the precise mechanisms underlying the release of cytokines from the respiratory epithelium are unclear. OBJECTIVES: The present study examines that extracellular signal-regulated kinase (ERK) activated downstream of the Ca(2+)-sensitive tyrosine kinase plays an important role in the efficient activation of the HDM-induced IL-8 signaling pathway. METHODS: We examined the effect of HDM, and the role of the Ca(2+)/calmodulin system and mitogen-activated protein kinases, on IL-8 expression in human lung epithelial cells. RESULTS: In H292 cells, HDM induced IL-8 release in a time- and/or dose-dependent manner. This IL-8 release was abolished by treatment with intracellular Ca(2+) chelator (BAPTA-AM), but not by EGTA or nifedipine. Calmodulin inhibitor (calmidazolium) and tyrosine kinase inhibitor (genistein) almost completely blocked IL-8 release by HDM. PD98,059, an ERK pathway inhibitor, completely abolished HDM-induced IL-8 release. Moreover, PD98,059, BAPTA-AM, calmidazolium and genistein suppressed the HDM-induced ERK phosphorylation. CONCLUSIONS: HDM-induced IL-8 production is predominantly regulated by Ca(2+)/calmodulin signaling, and ERK plays an important role in signal transmission for efficient activation of the HDM-induced IL-8 signaling pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 447~453 | - |
dc.relation.isPartOf | RESPIRATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Calcium-Calmodulin Mediates House Dust Mite-Induced ERK Activation and IL-8 Production in Human Respiratory Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.contributor.googleauthor | Jun Young Park | - |
dc.contributor.googleauthor | Eun-Soo Kim | - |
dc.contributor.googleauthor | Kyung-Won Kim | - |
dc.identifier.doi | 10.1159/000099264 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00805 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01673 | - |
dc.contributor.localId | A01967 | - |
dc.relation.journalcode | J02613 | - |
dc.identifier.eissn | 1423-0356 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/99264 | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Eun Soo | - |
dc.contributor.alternativeName | Park, Jun Young | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Eun Soo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Park, Jun Young | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 74 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 447 | - |
dc.citation.endPage | 453 | - |
dc.identifier.bibliographicCitation | RESPIRATION, Vol.74(4) : 447-453, 2007 | - |
dc.identifier.rimsid | 50452 | - |
dc.type.rims | ART | - |
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