Cited 26 times in
CART peptide 55-102 microinjected into the nucleus accumbens inhibits the expression of behavioral sensitization by amphetamine
DC Field | Value | Language |
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dc.contributor.author | 김정훈 | - |
dc.contributor.author | 윤형신 | - |
dc.date.accessioned | 2014-12-21T17:18:31Z | - |
dc.date.available | 2014-12-21T17:18:31Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0167-0115 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97344 | - |
dc.description.abstract | CART peptide has been shown to regulate the actions of psychomotor stimulants. Here we have further investigated the role of the biologically active CART 55-102 peptide in the nucleus accumbens (NAcc) in the expression of behavioral sensitization by amphetamine (AMPH). Rats were pre-exposed 5 times to either saline or AMPH (1 mg/kg, i.p.). After 2 weeks of withdrawal, rats were microinjected into the NAcc with saline or CART 55-102 (1.0, or 2.5 μg/0.5 μl/side) followed by AMPH challenge (1 mg/kg, i.p.). The enhanced increase of locomotion and rearing produced by repeated AMPH pre-exposures was dose-dependently inhibited by microinjection into the NAcc of CART 55-102 peptide. These results indicate that CART 55-102 peptide in the NAcc can play a compensatory inhibitory role in the expression of behavioral sensitization by AMPH and further suggest that CART peptide may be a useful target to control the drug addiction by psychomotor stimulants. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | REGULATORY PEPTIDES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | CART peptide 55-102 microinjected into the nucleus accumbens inhibits the expression of behavioral sensitization by amphetamine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Seungwoo Kim | - |
dc.contributor.googleauthor | Hyung Shin Yoon | - |
dc.contributor.googleauthor | Jeong-Hoon Kim | - |
dc.identifier.doi | 10.1016/j.regpep.2007.07.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00908 | - |
dc.relation.journalcode | J02602 | - |
dc.identifier.eissn | 1873-1686 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167011507001292 | - |
dc.contributor.alternativeName | Kim, Jeong Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 144 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 6 | - |
dc.citation.endPage | 9 | - |
dc.identifier.bibliographicCitation | REGULATORY PEPTIDES, Vol.144(1-3) : 6-9, 2007 | - |
dc.identifier.rimsid | 50451 | - |
dc.type.rims | ART | - |
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