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Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children

DC Field Value Language
dc.contributor.author김규언-
dc.contributor.author김은수-
dc.contributor.author손명현-
dc.contributor.author송태원-
dc.date.accessioned2014-12-21T17:16:44Z-
dc.date.available2014-12-21T17:16:44Z-
dc.date.issued2007-
dc.identifier.issn8755-6863-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97287-
dc.description.abstractCytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T lymphocyte activation. The gene encoding CTLA-4 is a candidate gene for conferring susceptibility to allergic disease. The purpose of this study was to evaluate the potential effects of CTLA-4 gene polymorphisms in Korean children on asthma. We genotyped 272 children with atopic asthma, 54 children with nonatopic asthma (NAA), and 254 control children for allelic determinants at two polymorphic sites in the region at positions promoter - 318 C > T and exon 1 + 49 G > A using restriction fragment length polymorphism methods. As a result, allele and genotype frequencies of the CTLA-4 exon 1 + 49 G > A polymorphism were different to some extent between the atopic asthma children and the controls with P<0.05, which did not reach statistical significance after the correction of multiple comparisons. In addition, CTLA-4 + 49 G > A polymorphism was significantly associated with elevated serum IgE levels (P=0.01). Of the four haplotype, haplotype 1 (C-G) was only associated with atopic asthma susceptibility after the correction of multiple comparisons (P=0.01, OR=0.702, 95% CI= 0.541-0.911). Polymorphisms in the CTLA-4 gene likely confer susceptibility to atopic asthma in Korean children.-
dc.description.statementOfResponsibilityopen-
dc.format.extent542~547-
dc.relation.isPartOfPEDIATRIC PULMONOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorSeung-Hyun Kim-
dc.contributor.googleauthorKyu-Earn Kim-
dc.contributor.googleauthorHae-Sim Park-
dc.contributor.googleauthorEun-Soo Kim-
dc.contributor.googleauthorKyung-Won Kim-
dc.contributor.googleauthorTae-Won Song-
dc.identifier.doi10.1002/ppul.20622-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00805-
dc.contributor.localIdA00327-
dc.contributor.localIdA01967-
dc.contributor.localIdA02072-
dc.contributor.localIdA00303-
dc.relation.journalcodeJ02491-
dc.identifier.eissn1099-0496-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ppul.20622/abstract-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameSong, Tae Won-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorSong, Tae Won-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.rights.accessRightsnot free-
dc.citation.volume42-
dc.citation.number6-
dc.citation.startPage542-
dc.citation.endPage547-
dc.identifier.bibliographicCitationPEDIATRIC PULMONOLOGY, Vol.42(6) : 542-547, 2007-
dc.identifier.rimsid49202-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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