Cited 89 times in
Clinical Outcome of Gastric Cancer Patients with Bone Marrow Metastases
DC Field | Value | Language |
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dc.contributor.author | 김효송 | - |
dc.date.accessioned | 2014-12-21T17:14:50Z | - |
dc.date.available | 2014-12-21T17:14:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97225 | - |
dc.description.abstract | BACKGROUND: Gastric cancer with bone marrow metastases is known to pursue a rapidly deteriorating clinical course. We conducted a retrospective analysis to evaluate clinical manifestations and prognosis of gastric cancer patients with bone marrow metastases. METHODS: Between September 1994 and February 2006, 39 gastric cancer patients with pathologically confirmed bone marrow dissemination were selected. RESULTS: The majority of the patients showed younger age, poorly differentiated adenocarcinoma or signet ring cell carcinoma, thrombocytopenia, anemia, elevated lactate dehydrogenase and alkaline phosphatase. Poor prognostic factors for survival were serum sodium < or =133 mmol/l [relative risk (RR) 4.57; 95% CI 1.99-10.52; p < 0.001], the presence of lung metastasis (RR 3.47; 95% CI 1.48-8.15; p = 0.007) and the presence of peritoneal seeding (RR 2.17; 95% CI 1.06-4.43; p = 0.036). Median survival durations after bone marrow metastases for patients without any adverse factors (n = 19, 48.7%) and those with 1-3 adverse factors (n = 20, 51.3%) were 67 and 23 days, respectively (p = 0.013). Patients without any adverse factors did benefit from palliative chemotherapy (p = 0.048). CONCLUSION: We suggest that gastric cancer patients with bone marrow metastases should receive more tailored therapies according to different risk factors in order to enhance survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 192~197 | - |
dc.relation.isPartOf | ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinical Outcome of Gastric Cancer Patients with Bone Marrow Metastases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Seong Yoon Yi | - |
dc.contributor.googleauthor | Won Ki Kang | - |
dc.contributor.googleauthor | Ho Yeong Lim | - |
dc.contributor.googleauthor | Younghyeh Ko | - |
dc.contributor.googleauthor | Hee-Jin Kim | - |
dc.contributor.googleauthor | Junho Jang | - |
dc.contributor.googleauthor | Young Suk Park | - |
dc.contributor.googleauthor | Joon Oh Park | - |
dc.contributor.googleauthor | Jeeyun Lee | - |
dc.contributor.googleauthor | Hyun Jung Jun | - |
dc.identifier.doi | 10.1159/000127386 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01202 | - |
dc.relation.journalcode | J02416 | - |
dc.identifier.eissn | 1423-0232 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/127386 | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 73 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 192 | - |
dc.citation.endPage | 197 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, Vol.73(3-4) : 192-197, 2007 | - |
dc.identifier.rimsid | 57813 | - |
dc.type.rims | ART | - |
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