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Alteration of brain metabolites in young alcoholics without structural changes

Authors
 Eun Lee  ;  Dong-Pyo Jang  ;  Kee Namkoong  ;  Kang-Jun Yoon  ;  Sun I. Kim  ;  In-Young Kim  ;  Sangjin Park  ;  Suk Kyoon An  ;  Jae-Jin Kim 
Citation
 NEUROREPORT, Vol.18(14) : 1511-1514, 2007 
Journal Title
 NEUROREPORT 
ISSN
 0959-4965 
Issue Date
2007
Abstract
Using proton magnetic resonance spectroscopy and magnetic resonance imaging, we investigated concentrations of various brain metabolites, including glutamate, and measured brain volumes and neuropsychological performances in 13 recently abstinent young alcoholic men compared with 18 controls. No differences were found in volumetric variables between groups (intracranial volume, white matter, grey matter, anterior cingulate, insula, hippocampus, and amygdala). For the anterior cingulate, choline and creatine levels in the patient group were significantly lower than controls, and the glutamate to creatine ratio was significantly increased. These were correlated with altered short-term memory functions. Thus, neurochemical changes can occur even in the brains of young alcoholic men lacking brain atrophy.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200709170-00021&LSLINK=80&D=ovft
DOI
10.1097/WNR.0b013e3282ef7625
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97195
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