Cited 263 times in
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
DC Field | Value | Language |
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dc.contributor.author | 박국인 | - |
dc.date.accessioned | 2014-12-21T17:13:13Z | - |
dc.date.available | 2014-12-21T17:13:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97173 | - |
dc.description.abstract | Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethal gangliosidosis. Although donor-derived neurons were electrophysiologically active within chimeric regions, the small degree of neuronal replacement alone could not account for the improvement. NSCs also increased brain beta-hexosaminidase levels, reduced ganglioside storage and diminished activated microgliosis. Additionally, when oral glycosphingolipid biosynthesis inhibitors (beta-hexosaminidase substrate inhibitors) were combined with NSC transplantation, substantial synergy resulted. Efficacy extended to human NSCs, both to those isolated directly from the central nervous system (CNS) and to those derived secondarily from embryonic stem cells. Appreciating that NSCs exhibit a broad repertoire of potentially therapeutic actions, of which neuronal replacement is but one, may help in formulating rational multimodal strategies for the treatment of neurodegenerative diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 439~447 | - |
dc.relation.isPartOf | NATURE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jean-Pyo Lee | - |
dc.contributor.googleauthor | Mylvaganam Jeyakumar | - |
dc.contributor.googleauthor | Evan Y Snyder | - |
dc.contributor.googleauthor | Frances M Platt | - |
dc.contributor.googleauthor | Thomas N Seyfried | - |
dc.contributor.googleauthor | Stuart A Lipton | - |
dc.contributor.googleauthor | David Wenger | - |
dc.contributor.googleauthor | Gang Tong | - |
dc.contributor.googleauthor | Philip Schwartz | - |
dc.contributor.googleauthor | Raymond A Dwek | - |
dc.contributor.googleauthor | Terry D Butters | - |
dc.contributor.googleauthor | Kook In Park | - |
dc.contributor.googleauthor | Franz-Josef Muller | - |
dc.contributor.googleauthor | Jennifer Meerloo | - |
dc.contributor.googleauthor | Scott McKercher | - |
dc.contributor.googleauthor | Jonathan Clarke | - |
dc.contributor.googleauthor | Gerald Fu | - |
dc.contributor.googleauthor | Heather Rose | - |
dc.contributor.googleauthor | Dan Clark | - |
dc.contributor.googleauthor | Rena C Baek | - |
dc.contributor.googleauthor | Pei-Jen Lee | - |
dc.contributor.googleauthor | Hiroto Takahashi | - |
dc.contributor.googleauthor | Rodolfo Gonzalez | - |
dc.identifier.doi | 10.1038/nm1548 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01438 | - |
dc.relation.journalcode | J02296 | - |
dc.identifier.eissn | 1546-170X | - |
dc.identifier.url | http://www.nature.com/nm/journal/v13/n4/full/nm1548.html | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 439 | - |
dc.citation.endPage | 447 | - |
dc.identifier.bibliographicCitation | NATURE MEDICINE, Vol.13(4) : 439-447, 2007 | - |
dc.identifier.rimsid | 55222 | - |
dc.type.rims | ART | - |
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