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Different cerebral cortical areas influence the effect of subthalamic nucleus stimulation on Parkinsonian motor deficits and freezing of gait

 Chul Hyoung Lyoo  ;  Sargo Aalto  ;  Myung Sik Lee  ;  Jin Woo Chang  ;  Seung Hun Oh  ;  Ki Ook Lee  ;  Juha O Rinne 
 MOVEMENT DISORDERS, Vol.22(15) : 2176-2182, 2007 
Journal Title
Issue Date
Inconsistent response in freezing of gait (FOG) with levodopa treatment or STN DBS makes the pathogenesis difficult to understand. We studied brain areas associated with the expression of STN DBS effect on parkinsonian motor deficits and FOG. Ten Parkinson's disease patients with typical FOG were included. One month before STN DBS, we performed [18F]-deoxyglucose PET scans and measured the UPDRS motor and modified FOG (mFOG) scores during levodopa off and on periods. At two months after STN DBS, same rating scores were measured. The percentage improvement of mFOG and UPDRS motor scores by STN DBS during levodopa off period was calculated. We searched for brain areas in which glucose metabolism correlated with the improvement of mFOG and UPDRS motor scores by DBS. During levodopa off period, STN DBS improved the UPDRS motor scores by 32.3% and the mFOG scores by 56.6%. There was no correlation between the improvements of both scores. The improvement of UPDRS motor score by DBS correlated with the metabolic activities of rostral supplementary motor area (Brodmann's area 8; BA8), anterior cingulate cortex (BA32), and prefrontal cortex (BA9). On the other hand, there was a positive correlation between the improvement of mFOG score by DBS and the metabolic activity of the parietal, occipital, and temporal sensory association cortices. In conclusion, dysfunction of different cerebral cortical areas limits the beneficial effects of DBS on parkinsonian motor deficits and FOG.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Oh, Seung Hun(오승헌)
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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