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Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma

DC Field Value Language
dc.contributor.author송태원-
dc.contributor.author김경원-
dc.contributor.author김규언-
dc.contributor.author김은수-
dc.contributor.author손명현-
dc.date.accessioned2014-12-21T17:11:56Z-
dc.date.available2014-12-21T17:11:56Z-
dc.date.issued2007-
dc.identifier.issn0341-2040-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97131-
dc.description.abstractThis study sought to evaluate the use of serum eosinophil-derived neurotoxin (EDN), which has been proposed as a marker of airway inflammation in asthma in the diagnosis and evaluation of the severity and bronchial hyperresponsiveness in childhood asthma. We studied 72 children with atopic asthma, 36 children with nonatopic asthma, and 43 healthy controls. Skin prick tests, pulmonary function tests, and methacholine challenge tests were performed, in addition to total eosinophil count, serum ECP, and EDN being measured in all subjects. EDN levels were significantly higher in the atopic asthma group than those in the nonatopic asthma group or control group (p < 0.001), as were ECP levels (p < 0.001). EDN levels differed more significantly among groups divided by asthma severity (p < 0.001) than did ECP levels for these groups (p < 0.05). For the groups divided according to bronchial hyperresponsiveness, both EDN and ECP levels were significantly different (p < 0.005 and p < 0.01, respectively). Significant correlations were found between EDN and PC20 (γ = −0.281; p < 0.001), between ECP and PC20 (γ = −0.274; p < 0.005), and between EDN and ECP (γ = 0.443; p < 0.001). In conclusion, serum EDN, as another marker of eosinophilic inflammation together with ECP, may aid in the diagnosis of asthma, especially atopic asthma, and in the evaluation of the severity and bronchial hyperresponsiveness in childhood asthma.-
dc.description.statementOfResponsibilityopen-
dc.format.extent97~103-
dc.relation.isPartOfLUNG-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSerum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorKyung Eun Lee-
dc.contributor.googleauthorKyu-Earn Kim-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorTae Won Song-
dc.contributor.googleauthorEun Soo Kim-
dc.identifier.doi10.1007/s00408-006-0054-8-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00805-
dc.contributor.localIdA02072-
dc.contributor.localIdA00303-
dc.contributor.localIdA00327-
dc.contributor.localIdA01967-
dc.relation.journalcodeJ02173-
dc.identifier.eissn1432-1750-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00408-006-0054-8-
dc.contributor.alternativeNameSong, Tae Won-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorSong, Tae Won-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.rights.accessRightsnot free-
dc.citation.volume185-
dc.citation.number2-
dc.citation.startPage97-
dc.citation.endPage103-
dc.identifier.bibliographicCitationLUNG, Vol.185(2) : 97-103, 2007-
dc.identifier.rimsid55193-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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