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상부요로 이행세포암에서 Cyclooxygenase-2 발현 및 미세혈관 밀도와 예후와의 연관성
DC Field | Value | Language |
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dc.contributor.author | 조강수 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2014-12-21T17:11:11Z | - |
dc.date.available | 2014-12-21T17:11:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97108 | - |
dc.description.abstract | Purpose The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 expression and microvessel density (MVD), a reflection of angiogenesis, with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Materials and Methods Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 91 patients, who had undergone radical nephroureterectomy, were examined immunohistochemically using antibodies against COX-2 and CD34. MVD was determined with CD34-stained slides. The expression patterns of COX-2 and MVD were compared with the clinicopathological variables. Results The COX-2 expression was significantly correlated with T stage (p=0.002), N stage (p=0.010), and grade (p=0.027). MVD was also significantly correlated with T stage (p<0.001), N stage (p=0.002), and grade (p=0.001). The COX-2 expression was significantly correlated with MVD (p=0.001). The survival rate of patients with COX-2 positive tumors or high MVD was significantly lower than that of patients with COX-2 negative tumors or low MVD, respectively (p=0.0013, p=0.0312). Univariate analyses identified T stage, N stage, grade, COX-2 expression, and MVD as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that T stage was the only independent prognostic factor. Conclusions The increased expression of COX-2 and MVD is associated with a worse prognosis in TCC-UUT. The COX-2 expression is correlated with MVD. These results suggest that COX-2 may play an important role in the progression of TCC-UUT and angiogenesis may be affected by COX-2 during the progression of TCC-UUT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 376~382 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 상부요로 이행세포암에서 Cyclooxygenase-2 발현 및 미세혈관 밀도와 예후와의 연관성 | - |
dc.title.alternative | Correlation of Cyclooxygenase-2 Expression and Microvessel Density with Prognosis in Transitional Cell Carcinoma of Upper Urinary Tract | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.contributor.googleauthor | 조남훈 | - |
dc.contributor.googleauthor | 조강수 | - |
dc.contributor.googleauthor | 임현이 | - |
dc.contributor.googleauthor | 조대성 | - |
dc.contributor.googleauthor | 차민호 | - |
dc.contributor.googleauthor | 김선일 | - |
dc.contributor.googleauthor | 안현수 | - |
dc.contributor.googleauthor | 김세중 | - |
dc.identifier.doi | 10.4111/kju.2007.48.4.376 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02135 | - |
dc.contributor.alternativeName | Cho, Kang Su | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Cho, Kang Su | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 376 | - |
dc.citation.endPage | 382 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.48(4) : 376-382, 2007 | - |
dc.identifier.rimsid | 55174 | - |
dc.type.rims | ART | - |
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