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자궁경부암에서 HLA-G와 IL-10의 발현 및 상호작용
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 김재욱 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 윤보성 | - |
dc.date.accessioned | 2014-12-21T17:07:13Z | - |
dc.date.available | 2014-12-21T17:07:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0494-4755 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96983 | - |
dc.description.abstract | Objectives: To determine the expression of HLA-G and IL-10 and their correlation in tissue of cervical cancer, and to investigate the relationship between their expression and clinicopathologic factors in patients with cervical cancer. Methods: Tissue samples were obtained from 40 patients diagnosed with cervical cancer and 15 patients with normal cervix for control from Oct. 2004 to Oct. 2005. Quantitative real-time RT-PCR for HLA-G mRNA and semi-quantitative RT-PCR for IL-10 mRNA were used. And proteins of HLA-G and IL-10 were detected by Western blot analysis. Results: Both HLA-G and IL-10 mRNA expression in cervical cancer tissue were higher than normal control, which was statistically significant (P<0.001, P<0.001). The proteins levels of HLA-G and IL-10 in cancer group were also significantly higher than control (P<0.001, P=0.041). The mRNA expression of HLA-G tended to be correlated with IL-10 expression (P=0.061), although it was not statistically significant. Among clinicopathologic factors of cervical cancer, there was inverse relationship between FIGO stage and mRNA value of HLA-G (P=0.045). Conclusions: The mRNA and protein expression of HLA-G and IL-10 in cervical cancer were much higher than in controls. These results showed that HLA-G and IL-10 might have an important role of tumorigenesis in patients with cervical cancer. The levels of HLA-G and IL-10 seem to be correlated although it was not statistically significant. High HLA-G mRNA expression could be related in early tumorigenesis since it was associated with early stage cervical cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 126~134 | - |
dc.relation.isPartOf | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 자궁경부암에서 HLA-G와 IL-10의 발현 및 상호작용 | - |
dc.title.alternative | The expression and interaction of HLA-G and IL-10 in cervical cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | 김영태 | - |
dc.contributor.googleauthor | 윤보성 | - |
dc.contributor.googleauthor | 남은지 | - |
dc.contributor.googleauthor | 김상운 | - |
dc.contributor.googleauthor | 김재훈 | - |
dc.contributor.googleauthor | 김성훈 | - |
dc.contributor.googleauthor | 김재욱 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00866 | - |
dc.contributor.localId | A00526 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A02554 | - |
dc.relation.journalcode | J02076 | - |
dc.identifier.url | http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2596736 | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Kim, Jae Wook | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Yoon, Bo Sung | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Wook | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Yoon, Bo Sung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 126 | - |
dc.citation.endPage | 134 | - |
dc.identifier.bibliographicCitation | Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.50(1) : 126-134, 2007 | - |
dc.identifier.rimsid | 37693 | - |
dc.type.rims | ART | - |
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