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자궁경부암에서 HLA-G와 IL-10의 발현 및 상호작용

DC Field Value Language
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author김재욱-
dc.contributor.author김재훈-
dc.contributor.author남은지-
dc.contributor.author윤보성-
dc.date.accessioned2014-12-21T17:07:13Z-
dc.date.available2014-12-21T17:07:13Z-
dc.date.issued2007-
dc.identifier.issn0494-4755-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96983-
dc.description.abstractObjectives: To determine the expression of HLA-G and IL-10 and their correlation in tissue of cervical cancer, and to investigate the relationship between their expression and clinicopathologic factors in patients with cervical cancer. Methods: Tissue samples were obtained from 40 patients diagnosed with cervical cancer and 15 patients with normal cervix for control from Oct. 2004 to Oct. 2005. Quantitative real-time RT-PCR for HLA-G mRNA and semi-quantitative RT-PCR for IL-10 mRNA were used. And proteins of HLA-G and IL-10 were detected by Western blot analysis. Results: Both HLA-G and IL-10 mRNA expression in cervical cancer tissue were higher than normal control, which was statistically significant (P<0.001, P<0.001). The proteins levels of HLA-G and IL-10 in cancer group were also significantly higher than control (P<0.001, P=0.041). The mRNA expression of HLA-G tended to be correlated with IL-10 expression (P=0.061), although it was not statistically significant. Among clinicopathologic factors of cervical cancer, there was inverse relationship between FIGO stage and mRNA value of HLA-G (P=0.045). Conclusions: The mRNA and protein expression of HLA-G and IL-10 in cervical cancer were much higher than in controls. These results showed that HLA-G and IL-10 might have an important role of tumorigenesis in patients with cervical cancer. The levels of HLA-G and IL-10 seem to be correlated although it was not statistically significant. High HLA-G mRNA expression could be related in early tumorigenesis since it was associated with early stage cervical cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent126~134-
dc.relation.isPartOfKorean Journal of Obstetrics and Gynecology (대한산부인과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title자궁경부암에서 HLA-G와 IL-10의 발현 및 상호작용-
dc.title.alternativeThe expression and interaction of HLA-G and IL-10 in cervical cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthor김영태-
dc.contributor.googleauthor윤보성-
dc.contributor.googleauthor남은지-
dc.contributor.googleauthor김상운-
dc.contributor.googleauthor김재훈-
dc.contributor.googleauthor김성훈-
dc.contributor.googleauthor김재욱-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00595-
dc.contributor.localIdA00866-
dc.contributor.localIdA00526-
dc.contributor.localIdA00729-
dc.contributor.localIdA00876-
dc.contributor.localIdA01262-
dc.contributor.localIdA02554-
dc.relation.journalcodeJ02076-
dc.identifier.urlhttp://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2596736-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameKim, Jae Wook-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNameYoon, Bo Sung-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Jae Wook-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorKim, Jae Hoon-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorYoon, Bo Sung-
dc.rights.accessRightsnot free-
dc.citation.volume50-
dc.citation.number1-
dc.citation.startPage126-
dc.citation.endPage134-
dc.identifier.bibliographicCitationKorean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.50(1) : 126-134, 2007-
dc.identifier.rimsid37693-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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