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당뇨 백서 사구체 및 고포도당으로 자극한 족세포에서 싸이클로스포린이 P-cadherin의 발현에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 이정은 | - |
dc.contributor.author | 최훈영 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 김동기 | - |
dc.contributor.author | 김주성 | - |
dc.contributor.author | 류동열 | - |
dc.date.accessioned | 2014-12-21T17:07:05Z | - |
dc.date.available | 2014-12-21T17:07:05Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1975-9460 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96979 | - |
dc.description.abstract | Purpose: We investigated whether Cyclosporin A (CsA) had the anti-proteinuric effect in diabetic rats and whether it was associated with the alteration of P- cadherin expression. Methods: Sprague-Dawley rats were injected with diluent (C, N=16) or streptozotocin intraperitoneally (DM, N=16). Eight rats in each group were treated with 10% ethanol or with 1.5 mg/kg/day of CsA (C+CsA and DM+CsA) for 6 weeks. Immortalized mouse podocytes were cultured in media with 5.6 mM glucose (LG), LG+CsA (10-8 M), LG+TGF-β1, 30 mM glucose (HG), or HG+CsA. Real time-PCR and Western blot were performed for P-cadherin and TGF-β1 mRNA and protein expression, respectively, with sieved glomeruli and cell lysates. Results: Urinary albumin excretion was significantly higher in DM compared with C rats, and CsA treatment inhibited the increase in albuminuria in DM rats. Glomerular P-cadherin mRNA and protein expression in DM were decreased compared with C rats, and these decreases were significantly inhibited by CsA. Glomerular TGF-β1 mRNA and protein expression were higher in DM than C rats, and CsA treatment inhibited the increase in TGF-β1 expression in DM. P-cadherin mRNA and protein expression in HG and LG+TGF-β1 podocytes were lower than LG cells, and these HG-induced decrements were restored by CsA. Conclusion: CsA treatment reduces urinary albumin excretion in DM rats. P-cadherin expression is decreased under diabetic conditions, which is ameliorated by CsA. In addition, inhibition of the increase in glomerular TGF-β1 expression under diabetic conditions by CsA seems to restore the P-cadherin expression, resulting in the decrease in albuminuria. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 23~33 | - |
dc.relation.isPartOf | Korean Journal of Nephrology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 당뇨 백서 사구체 및 고포도당으로 자극한 족세포에서 싸이클로스포린이 P-cadherin의 발현에 미치는 영향 | - |
dc.title.alternative | The Effect of Cyclosporine on P-cadherin Expression in Experimental Diabetic Nephropathy and Glucose-Stimulated Podocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 강신욱 | - |
dc.contributor.googleauthor | 유태현 | - |
dc.contributor.googleauthor | 류동열 | - |
dc.contributor.googleauthor | 한대석 | - |
dc.contributor.googleauthor | 이정은 | - |
dc.contributor.googleauthor | 이태희 | - |
dc.contributor.googleauthor | 김동기 | - |
dc.contributor.googleauthor | 한승혁 | - |
dc.contributor.googleauthor | 곽승재 | - |
dc.contributor.googleauthor | 김진주 | - |
dc.contributor.googleauthor | 정동섭 | - |
dc.contributor.googleauthor | 김주성 | - |
dc.contributor.googleauthor | 최훈영 | - |
dc.contributor.googleauthor | 김형종 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04226 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00934 | - |
dc.contributor.localId | A01323 | - |
dc.contributor.localId | A03119 | - |
dc.contributor.localId | A00400 | - |
dc.relation.journalcode | J02065 | - |
dc.contributor.alternativeName | Lee, Jung Eun | - |
dc.contributor.alternativeName | Choi, Hoon Young | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Kim, Dong Ki | - |
dc.contributor.alternativeName | Kim, Joo Sung | - |
dc.contributor.alternativeName | Ryu, Dong Ryeol | - |
dc.contributor.affiliatedAuthor | Choi, Hoon Young | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Kim, Joo Sung | - |
dc.contributor.affiliatedAuthor | Ryu, Dong Ryeol | - |
dc.contributor.affiliatedAuthor | Lee, Jung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 33 | - |
dc.identifier.bibliographicCitation | Korean Journal of Nephrology, Vol.26(1) : 23-33, 2007 | - |
dc.identifier.rimsid | 37691 | - |
dc.type.rims | ART | - |
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