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Methicillin 내성 Staphylococcus 검출을 위한 Cefoxitin과 Oxacillin디스크 시험법에서 불일치를 보인 균주에서의 mecA 유전자 검출

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dc.contributor.author김창기-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정윤섭-
dc.date.accessioned2014-12-21T17:06:17Z-
dc.date.available2014-12-21T17:06:17Z-
dc.date.issued2007-
dc.identifier.issn1598-6535-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96954-
dc.description.abstractBackground :Cinical and Laboratory Standards Institute (CLSI) recommends the use of cefoxitin disks instead of long-used oxacillin disks for screening methicillin-resistant isolates of staphylococci. The frequency of discrepant results and accuracy of the tests were evaluated by detecting mecA gene. Method :A total of 3,123 Stapylococci isolates from patients in Severance Hospital were tested during September 2005 to August 2006 by the CLSI-recommended test using both cefoxitin and oxacillin disks. The mecA gene was detected by PCR and the oxacillin minimum inhibitory concentration (MIC) was determined by using agar dilution method for the isolates with discrepant tests. Result :Among 1,915 S. aureus islolates tested, one isolate was resistant to oxacillin disk but susceptible to cefoxitin disk; the isolate did not have mecA gene. Another isolate susceptible to oxacillin but resistant to cefoxitin had mecA gene. Among 1,208 coagulase-negative staphylococcal isolates, 15 isolates were resistant to oxacillin disk but susceptible to cefoxitin disk; the isolates did not have mecA genes. Two isolates susceptible to oxacillin disk but resistant to cefoxitin disk had mecA genes. Among the 16 Staphylococcus isolates that did not have mecA gene, 15 isolates had the oxacillin MICs of 2 g/mL and were considered as methicillin-susceptible, while 1 isolate with the MIC of 4 g/mL was considered as methicillin-resistant. Conclusion :Overall, 1.9% of staphylococcal isolates showed discrepant results when the screening tests were performed by using oxacillin and cefoxitin disks. None of the isolates resistant to oxacillin disk but susceptible to cefoxitin disk had mecA gene. In conclusion, the cefoxitin disk test is more reliable than oxacillin disk test in screening methicillin-resistant staphylococcal isolates.-
dc.description.statementOfResponsibilityopen-
dc.format.extent276~280-
dc.relation.isPartOfKOREAN JOURNAL OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMethicillin 내성 Staphylococcus 검출을 위한 Cefoxitin과 Oxacillin디스크 시험법에서 불일치를 보인 균주에서의 mecA 유전자 검출-
dc.title.alternativeDetection of mecA in Strains with Oxacillin and Cefoxitin Disk Tests for Detection of Methicillin-resistant Staphylococcus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthor이양순-
dc.contributor.googleauthor김창기-
dc.contributor.googleauthor정윤섭-
dc.contributor.googleauthor이경원-
dc.contributor.googleauthor용동은-
dc.contributor.googleauthor김명숙-
dc.identifier.doi10.3343/kjlm.2007.27.4.276-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01038-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03679-
dc.relation.journalcodeJ02044-
dc.contributor.alternativeNameKim, Chang Ki-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameChong, Yun Sop-
dc.contributor.affiliatedAuthorKim, Chang Ki-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorChong, Yun Sop-
dc.rights.accessRightsfree-
dc.citation.volume27-
dc.citation.number4-
dc.citation.startPage276-
dc.citation.endPage280-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF LABORATORY MEDICINE , Vol.27(4) : 276-280, 2007-
dc.identifier.rimsid37676-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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