골수이형성 증후군 환자에서 발생한 조직구양 Sweet 증후군 1예

Abstract

Sweet`s syndrome is an acute febrile neutrophilic dermatosis that occurs with malignant disease, mainly myeloid hemopathies, in about 20% of cases. When associated with myelodysplasia, clinical and histologic features of Sweet`s syndrome can be atypical; however its significance is still debated. We encountered a case of Sweet`s syndrome associated with myelodysplastic syndrome in a 63-year-old woman. The clinical presentation strongly suggested Sweet`s syndrome but, histopathologic examination showed dense histiocytic infiltration with prominent upper dermal edema and little neutrophil infiltration. In the evaluation for atypical histopathology and laboratory abnormalities, she was diagnosed with myleodysplastic syndrome by peripheral blood smear and bone marrow biopsy. Histiocytoid Sweet`s syndrome is a currently accepted concept and probably has a close relation with underlying myeloid hemopathies.