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Effect of Alfentanil on the Intraoperative Localization of an Epileptogenic Focus in Pediatric Patients with Intractable Seizure Disorder
DC Field | Value | Language |
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dc.contributor.author | 민경태 | - |
dc.contributor.author | 이성진 | - |
dc.contributor.author | 최병인 | - |
dc.contributor.author | 최승호 | - |
dc.date.accessioned | 2014-12-21T17:02:26Z | - |
dc.date.available | 2014-12-21T17:02:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 2005-6419 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96829 | - |
dc.description.abstract | Background : Intraoperative alfentanil is known to increase the epileptic discharge in the adult seizure patients. This study hypothesized that alfentanil might localize an epileptogenic focus in pediatric seizure patients. Methods : This study was performed in the pediatric seizure patients who undergo second-staged operation. Thirteen pediatric patients were enrolled and their epileptic foci were already suspected from first operation. After anesthetic induction, sevoflurane was maintained at 0.6% end-tidal concentration for study period. Electrocorticography (ECoG) was recorded for 5 minutes before and 5 minutes after alfentanil 20µg/kg IV. During the ECoG recordings, the mean arterial pressure (MAP) and heart rate (HR) were continuously monitored. After the surgery, a pediatric neurologist analyzed the changes of spike frequencies of suspected ictal zone. The spike frequencies of suspected non-ictal zone were also calculated in five patients. The suspected ictal zone was defined as the most abundant spontaneous spiking area observed after first staged grid insertion. Results : Alfentanil induced a significant increase in spike activity of suspected ictal zone in 12 out of 13 patients (median of 20 [ranged 10 to 100] vs 38 [ranged 20 to 100], P < 0.05). Alfentanil-induced increase of spike activity was prominent in the suspected ictal zone rather than non-ictal zone. There were no significant changes in the MAP and HR after administration of alfentanil. Conclusions : Alfentanil activates epileptiform activity of suspected ictal zone in pediatric patients with seizure disorder and can be used to assist in the localization of the epileptogenic focus during seizure surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | S47~S52 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of Alfentanil on the Intraoperative Localization of an Epileptogenic Focus in Pediatric Patients with Intractable Seizure Disorder | - |
dc.title.alternative | 난치성 경련 질환 환아에서 Alfentanil이 간질 유발부위의 국소화에 미치는 영향 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Byung In Choi | - |
dc.contributor.googleauthor | Sung Jin Lee | - |
dc.contributor.googleauthor | Seung Ho Choi | - |
dc.contributor.googleauthor | Kyeong Tae Min | - |
dc.contributor.googleauthor | Bahn Lee | - |
dc.identifier.doi | 10.4097/kjae.2007.52.6.S47 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01400 | - |
dc.contributor.localId | A02872 | - |
dc.contributor.localId | A04060 | - |
dc.contributor.localId | A04101 | - |
dc.relation.journalcode | J03189 | - |
dc.identifier.eissn | 2005-7563 | - |
dc.contributor.alternativeName | Min, Kyeong Tae | - |
dc.contributor.alternativeName | Lee, Sung Jin | - |
dc.contributor.alternativeName | Choi, Byung In | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.affiliatedAuthor | Min, Kyeong Tae | - |
dc.contributor.affiliatedAuthor | Lee, Sung Jin | - |
dc.contributor.affiliatedAuthor | Choi, Byung In | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 52 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 52 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF ANESTHESIOLOGY, Vol.52(6) : 47-52, 2007 | - |
dc.identifier.rimsid | 36928 | - |
dc.type.rims | ART | - |
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