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Effect of Alfentanil on the Intraoperative Localization of an Epileptogenic Focus in Pediatric Patients with Intractable Seizure Disorder

DC Field Value Language
dc.contributor.author민경태-
dc.contributor.author이성진-
dc.contributor.author최병인-
dc.contributor.author최승호-
dc.date.accessioned2014-12-21T17:02:26Z-
dc.date.available2014-12-21T17:02:26Z-
dc.date.issued2007-
dc.identifier.issn2005-6419-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96829-
dc.description.abstractBackground : Intraoperative alfentanil is known to increase the epileptic discharge in the adult seizure patients. This study hypothesized that alfentanil might localize an epileptogenic focus in pediatric seizure patients. Methods : This study was performed in the pediatric seizure patients who undergo second-staged operation. Thirteen pediatric patients were enrolled and their epileptic foci were already suspected from first operation. After anesthetic induction, sevoflurane was maintained at 0.6% end-tidal concentration for study period. Electrocorticography (ECoG) was recorded for 5 minutes before and 5 minutes after alfentanil 20µg/kg IV. During the ECoG recordings, the mean arterial pressure (MAP) and heart rate (HR) were continuously monitored. After the surgery, a pediatric neurologist analyzed the changes of spike frequencies of suspected ictal zone. The spike frequencies of suspected non-ictal zone were also calculated in five patients. The suspected ictal zone was defined as the most abundant spontaneous spiking area observed after first staged grid insertion. Results : Alfentanil induced a significant increase in spike activity of suspected ictal zone in 12 out of 13 patients (median of 20 [ranged 10 to 100] vs 38 [ranged 20 to 100], P < 0.05). Alfentanil-induced increase of spike activity was prominent in the suspected ictal zone rather than non-ictal zone. There were no significant changes in the MAP and HR after administration of alfentanil. Conclusions : Alfentanil activates epileptiform activity of suspected ictal zone in pediatric patients with seizure disorder and can be used to assist in the localization of the epileptogenic focus during seizure surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extentS47~S52-
dc.relation.isPartOfKOREAN JOURNAL OF ANESTHESIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffect of Alfentanil on the Intraoperative Localization of an Epileptogenic Focus in Pediatric Patients with Intractable Seizure Disorder-
dc.title.alternative난치성 경련 질환 환아에서 Alfentanil이 간질 유발부위의 국소화에 미치는 영향-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorByung In Choi-
dc.contributor.googleauthorSung Jin Lee-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorKyeong Tae Min-
dc.contributor.googleauthorBahn Lee-
dc.identifier.doi10.4097/kjae.2007.52.6.S47-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01400-
dc.contributor.localIdA02872-
dc.contributor.localIdA04060-
dc.contributor.localIdA04101-
dc.relation.journalcodeJ03189-
dc.identifier.eissn2005-7563-
dc.contributor.alternativeNameMin, Kyeong Tae-
dc.contributor.alternativeNameLee, Sung Jin-
dc.contributor.alternativeNameChoi, Byung In-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.affiliatedAuthorMin, Kyeong Tae-
dc.contributor.affiliatedAuthorLee, Sung Jin-
dc.contributor.affiliatedAuthorChoi, Byung In-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.rights.accessRightsfree-
dc.citation.volume52-
dc.citation.number6-
dc.citation.startPage47-
dc.citation.endPage52-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF ANESTHESIOLOGY, Vol.52(6) : 47-52, 2007-
dc.identifier.rimsid36928-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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