Expression of Viral MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma

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Authors: Do Nyun Kim ; Hiun-Suk Chae ; Suk Kyeong Lee ; Won-Keun Lee ; Jae Myun Lee ; Kenzo Takada ; Won Sang Park ; Cho Hyun Park ; Jin-Hyoung Kang ; Sang Taek Oh

MeSH: Animals ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Viral* ; Herpesvirus 4, Human/genetics* ; Herpesvirus 4, Human/pathogenicity* ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism* ; Stomach Neoplasms/virology* ; Viral Proteins/genetics

Abstract: Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.