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Expression of Viral MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma

Authors
 Do Nyun Kim  ;  Hiun-Suk Chae  ;  Suk Kyeong Lee  ;  Won-Keun Lee  ;  Jae Myun Lee  ;  Kenzo Takada  ;  Won Sang Park  ;  Cho Hyun Park  ;  Jin-Hyoung Kang  ;  Sang Taek Oh 
Citation
 Journal of Virology, Vol.81(2) : 1033-1036, 2007 
Journal Title
 Journal of Virology 
ISSN
 0022-538X 
Issue Date
2007
MeSH
Animals ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Viral* ; Herpesvirus 4, Human/genetics* ; Herpesvirus 4, Human/pathogenicity* ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism* ; Stomach Neoplasms/virology* ; Viral Proteins/genetics
Abstract
Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.
Files in This Item:
T200700710.pdf Download
DOI
10.1128/JVI.02271-06
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Myun(이재면) ORCID logo https://orcid.org/0000-0002-5273-3113
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96726
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