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다양한 신질환을 가진 소아에서 Cystatin C 검사의임상적 유용성

DC Field Value Language
dc.contributor.author임종백-
dc.contributor.author신재일-
dc.contributor.author이재승-
dc.date.accessioned2014-12-21T16:57:44Z-
dc.date.available2014-12-21T16:57:44Z-
dc.date.issued2007-
dc.identifier.issn1226-5292-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96680-
dc.description.abstractPurpose GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C. Methods We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/1.73m2, Group 2 : CrCl 40-60 mL/min/1.73m2, Group 3 : CrCl >60 mL/min/1.73m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them. Results Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%). Conclusion Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.-
dc.description.statementOfResponsibilityopen-
dc.format.extent161~167-
dc.relation.isPartOfJournal of the Korean Society of Pediatric Nephrology (대한소아신장학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title다양한 신질환을 가진 소아에서 Cystatin C 검사의임상적 유용성-
dc.title.alternativeThe Clinical Usefulness of Cystatin C in Evaluating RenalFunction in Children with Various Renal Diseases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthor김기주-
dc.contributor.googleauthor김정아-
dc.contributor.googleauthor임종백-
dc.contributor.googleauthor이재승-
dc.contributor.googleauthor정일천-
dc.contributor.googleauthor황유식-
dc.contributor.googleauthor신재일-
dc.identifier.doi10.3339/jkspn.2007.11.2.161-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03403-
dc.contributor.localIdA02142-
dc.contributor.localIdA03076-
dc.relation.journalcodeJ01885-
dc.subject.keywordGlomerular filtration rate-
dc.subject.keywordCystatin C-
dc.subject.keywordCreatinine-
dc.subject.keywordCreatinine Clearance-
dc.contributor.alternativeNameLim, Jong Baeck-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.alternativeNameLee, Jae Seung-
dc.contributor.affiliatedAuthorLim, Jong Baeck-
dc.contributor.affiliatedAuthorShin, Jae Il-
dc.contributor.affiliatedAuthorLee, Jae Seung-
dc.rights.accessRightsfree-
dc.citation.volume11-
dc.citation.number2-
dc.citation.startPage161-
dc.citation.endPage167-
dc.identifier.bibliographicCitationJournal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.11(2) : 161-167, 2007-
dc.identifier.rimsid36405-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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