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다양한 신질환을 가진 소아에서 Cystatin C 검사의임상적 유용성
DC Field | Value | Language |
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dc.contributor.author | 임종백 | - |
dc.contributor.author | 신재일 | - |
dc.contributor.author | 이재승 | - |
dc.date.accessioned | 2014-12-21T16:57:44Z | - |
dc.date.available | 2014-12-21T16:57:44Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-5292 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96680 | - |
dc.description.abstract | Purpose GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C. Methods We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/1.73m2, Group 2 : CrCl 40-60 mL/min/1.73m2, Group 3 : CrCl >60 mL/min/1.73m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them. Results Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%). Conclusion Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 161~167 | - |
dc.relation.isPartOf | Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 다양한 신질환을 가진 소아에서 Cystatin C 검사의임상적 유용성 | - |
dc.title.alternative | The Clinical Usefulness of Cystatin C in Evaluating RenalFunction in Children with Various Renal Diseases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 김기주 | - |
dc.contributor.googleauthor | 김정아 | - |
dc.contributor.googleauthor | 임종백 | - |
dc.contributor.googleauthor | 이재승 | - |
dc.contributor.googleauthor | 정일천 | - |
dc.contributor.googleauthor | 황유식 | - |
dc.contributor.googleauthor | 신재일 | - |
dc.identifier.doi | 10.3339/jkspn.2007.11.2.161 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03403 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A03076 | - |
dc.relation.journalcode | J01885 | - |
dc.subject.keyword | Glomerular filtration rate | - |
dc.subject.keyword | Cystatin C | - |
dc.subject.keyword | Creatinine | - |
dc.subject.keyword | Creatinine Clearance | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.alternativeName | Lee, Jae Seung | - |
dc.contributor.affiliatedAuthor | Lim, Jong Baeck | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 161 | - |
dc.citation.endPage | 167 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.11(2) : 161-167, 2007 | - |
dc.identifier.rimsid | 36405 | - |
dc.type.rims | ART | - |
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