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다양한 신질환을 가진 소아에서 Cystatin C 검사의임상적 유용성

Other Titles
 The Clinical Usefulness of Cystatin C in Evaluating RenalFunction in Children with Various Renal Diseases 
Authors
 김기주  ;  김정아  ;  임종백  ;  이재승  ;  정일천  ;  황유식  ;  신재일 
Citation
 Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.11(2) : 161-167, 2007 
Journal Title
 Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지) 
ISSN
 1226-5292 
Issue Date
2007
Keywords
Glomerular filtration rate ; Cystatin C ; Creatinine ; Creatinine Clearance
Abstract
Purpose GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C. Methods We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/1.73m2, Group 2 : CrCl 40-60 mL/min/1.73m2, Group 3 : CrCl >60 mL/min/1.73m2). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them. Results Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%). Conclusion Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.
Files in This Item:
T200701649.pdf Download
DOI
10.3339/jkspn.2007.11.2.161
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Jae Seung(이재승)
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96680
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