한국인에서 Dupuytren 질환과 흡연 및 알코올 섭취와의 관련성 연구

Abstract

Purpose: This study evaluated the relationship between Dupuytrens disease and smoking and alcohol intake. Materials and Methods: Forty eight patients with Dupuytrens disease, who underwent a partial fasiectomy were examined retrospectively through a chart review and a telephone interview. The minimum follow-up period was 12 months. The relationship between Dupuytren’s disease and smoking and alcohol intake were analyzed using multivariate logistic regression with significance set at p ＜ 0.05. Results: Dupuytren’s disease requiring surgery in these patients was associated with heavy alcohol intake (odds ratio 2.91) and alcohol intake per week (odds ratio 1.22). The average smoking level was 24.7 pack-year for cases compared with 16.1 pack-year for controls (p＜0.05). The average alcohol intake was 3.0 units per week for the cases compared with 1.2 units per week for controls (p＜0.05). Smoking was not an independent risk factor but increased the risk when combined with heavy alcohol intake. Conclusion: Heavy alcohol intake is an independent risk factor of Dupuytren’s disease in Korean. Smoking is not an independent risk factor but increases the risk when combined with heavy alcohol intake.