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Outcome of Multipair Donor Kidney Exchange by a Web-Based Algorithm

 Beom Seok Kim  ;  Yu Seun Kim  ;  Dae Joong Kim  ;  Ha-Young Oh  ;  Sung Joo Kim  ;  Yon Su Kim  ;  Duck Jong Han  ;  Bum Soon Choi  ;  Chul Woo Yang  ;  Chan Duck Kim  ;  Yong-Lim Kim  ;  Ho Yung Lee  ;  Myoung Soo Kim  ;  Soon Il Kim 
 Journal of the American Society of Nephrology, Vol.18(3) : 1000-1006, 2007 
Journal Title
 Journal of the American Society of Nephrology 
Issue Date
ABO Blood-Group System/immunology* ; Adult ; Aged ; Algorithms* ; Blood Grouping and Crossmatching/methods* ; Computers ; Donor Selection/methods ; Female ; Humans ; Internet ; Kidney Transplantation/immunology* ; Korea ; Living Donors ; Male ; Middle Aged ; Tissue and Organ Procurement/methods* ; Tissue and Organ Procurement/organization & administration
Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange combinations not only between two incompatible DRP but also circularly among three DRP and selects an optimum set of exchange combinations, considering several factors that can affect the outcome of the exchanged transplant. The algorithm was implemented as a web-based program, and matching was performed five times. Fifty-three DRP were enrolled from five transplant centers. The numbers of DRP that were enrolled in each matching were 38 (25:13), 39 (34:5), 33 (31:2), 32 (28:4), and 34 (30:4) (carryover:newcomer). The numbers of generated exchange combinations were 4:11, 3:17, 2:12, 2:3, and 2:3 (two-pair exchange:three-pair exchange), and the numbers of DRP in selected exchange combinations were six, 12, six, five, and four in each matching. The numbers of DRP with blood type O recipient or AB donor were five and one, respectively, in selected exchange combinations. Six DRP of two-pair exchange combinations and six DRP of three-pair exchange combinations underwent transplantation successfully. Computerized algorithm of donor kidney exchange was tried not only between two incompatible DRP but also circularly among three DRP. It showed that the algorithm has potential to improve the outcome of donor kidney exchange, especially for disadvantaged DRP with blood type O recipients or AB donors.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Lee, Ho Yung(이호영)
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