Cited 95 times in
The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer
DC Field | Value | Language |
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dc.contributor.author | 강창무 | - |
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김병로 | - |
dc.contributor.author | 김준영 | - |
dc.contributor.author | 이우정 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2014-12-21T16:53:11Z | - |
dc.date.available | 2014-12-21T16:53:11Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0022-4804 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96536 | - |
dc.description.abstract | BACKGROUND: Despite the usefulness of CA 19-9 in the diagnosis and prognosis of pancreatic cancer, cholestasis can falsely elevate CA 19-9 levels, which contributes to limited clinical utility in patients with biliary obstruction. This study was designed to evaluate the usefulness of adjusted preoperative CA 19-9 levels in predicting a prognosis of pancreatic cancer. METHODS: The available medical records of patients with resected pancreatic cancer from January 1990 to June 2005 were retrospectively viewed at Yonsei Medical Center, Seoul, Korea. The adjusted CA 19-9 value was obtained by dividing the serum CA 19-9 level by the values of serum bilirubin in case of bilirubin greater, similar 2 mg/dL. Disease-free survival was evaluated according to the adjusted preoperative CA 19-9 value. RESULTS: Sixty-one patients were investigated. Their adjusted preoperative CA 19-9 values were significantly different from the actual baseline CA 19-9 value (129.4 +/- 225.2 U/mL, versus 442.1 +/- 645.5 U/mL, P < 0.0001). On univariate analysis, peripancreatic microscopic invasion (P = 0.0142), lymphovascular invasion (P = 0.0038), and adjusted preoperative CA 19-9 > or = 50 U/mL (P = 0.0049) were predictive factors for cancer recurrence after curative resection. Adjusted preoperative CA 19-9 > or = 50 U/mL (Exp (B) = 2.097, P = 0.027) was an independent predictive factor in multivariate analysis. CONCLUSIONS: The adjusted preoperative CA 19-9 value can predict the risk of recurrence after curative resection of pancreatic cancer. Interpreting the preoperative CA 19-9 value adjusted to the serum bilirubin values seems to be more reasonable in evaluating prognosis of pancreatic cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 31~35 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/blood | - |
dc.subject.MESH | Adenocarcinoma/diagnosis* | - |
dc.subject.MESH | Adenocarcinoma/epidemiology | - |
dc.subject.MESH | Adenocarcinoma/surgery* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/blood | - |
dc.subject.MESH | CA-19-9 Antigen/blood* | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/blood | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/epidemiology | - |
dc.subject.MESH | Pancreatic Neoplasms/blood | - |
dc.subject.MESH | Pancreatic Neoplasms/diagnosis* | - |
dc.subject.MESH | Pancreatic Neoplasms/epidemiology | - |
dc.subject.MESH | Pancreatic Neoplasms/surgery* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Preoperative Care | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Jun Young Kim | - |
dc.contributor.googleauthor | Byong Ro Kim | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.identifier.doi | 10.1016/j.jss.2006.10.007 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00088 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00496 | - |
dc.contributor.localId | A00955 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.relation.journalcode | J01763 | - |
dc.identifier.eissn | 1095-8673 | - |
dc.identifier.pmid | 17418869 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022480406005300 | - |
dc.contributor.alternativeName | Kang, Chang Moo | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Byong Ro | - |
dc.contributor.alternativeName | Kim, Jun Young | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.alternativeName | Choi, Gi Hong | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | Kang, Chang Moo | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Byong Ro | - |
dc.contributor.affiliatedAuthor | Kim, Jun Young | - |
dc.contributor.affiliatedAuthor | Choi, Gi Hong | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 140 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 35 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL RESEARCH, Vol.140(1) : 31-35, 2007 | - |
dc.identifier.rimsid | 36147 | - |
dc.type.rims | ART | - |
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