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Identification of Proteins that Regulate Radiation-induced Apoptosis in Murine Tumors with Wild Type p53
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2014-12-21T16:52:39Z | - |
dc.date.available | 2014-12-21T16:52:39Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0449-3060 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96520 | - |
dc.description.abstract | In this study, we investigated the molecular factors determining the induction of apoptosis by radiation. Two murine tumors syngeneic to C3H/HeJ mice were used: an ovarian carcinoma OCa-I, and a hepatocarcinoma HCa-I. Both have wild type p53, but display distinctly different radiosensitivity in terms of specific growth delay (12.7 d in OCa-I and 0.3 d in HCa-I) and tumor cure dose 50% (52.6 Gy in OCa-I and > 80 Gy in HCa-I). Eight-mm tumors on the thighs of mice were irradiated with 25 Gy and tumor samples were collected at regular time intervals after irradiation. The peak levels of apoptosis were 16.1 ± 0.6% in OCa-I and 0.2 ± 0.0% in HCa-I at 4 h after radiation, and this time point was used for subsequent proteomics analysis. Protein spots were identified by peptide mass fingerprinting with a focus on those related to apoptosis. In OCa-I tumors, radiation increased the expression of cytochrome c oxidase and Bcl2/adenovirus E1B-interacting 2 (Nip 2) protein higher than 3-fold. However in HCa-I, these two proteins showed no significant change. The results suggest that radiosensitivity in tumors with wild type p53 is regulated by a complex mechanism. Furthermore, these proteins could be molecular targets for a novel therapeutic strategy involving the regulation of radiosensitivity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 435~441 | - |
dc.relation.isPartOf | JOURNAL OF RADIATION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/radiation effects* | - |
dc.subject.MESH | Apoptosis Regulatory Proteins/metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Liver Neoplasms/metabolism* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C3H | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism* | - |
dc.subject.MESH | Ovarian Neoplasms/pathology | - |
dc.subject.MESH | Radiation Dosage | - |
dc.subject.MESH | Tumor Suppressor Protein p53/metabolism* | - |
dc.title | Identification of Proteins that Regulate Radiation-induced Apoptosis in Murine Tumors with Wild Type p53 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Jinsil SEONG | - |
dc.contributor.googleauthor | Hae Jin OH | - |
dc.contributor.googleauthor | Wonwoo KIM | - |
dc.contributor.googleauthor | Jeung Hee AN | - |
dc.contributor.googleauthor | Jiyoung KIM | - |
dc.identifier.doi | 10.1269/jrr.07015 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J01727 | - |
dc.identifier.eissn | 1349-9157 | - |
dc.identifier.pmid | 17721044 | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 435 | - |
dc.citation.endPage | 441 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RADIATION RESEARCH, Vol.48(5) : 435-441, 2007 | - |
dc.identifier.rimsid | 36136 | - |
dc.type.rims | ART | - |
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