Cited 51 times in
Clinical outcome of renal transplantation in patients with positive pre-transplant hepatitis B surface antigen
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 주만기 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 안형준 | - |
dc.date.accessioned | 2014-12-21T16:51:17Z | - |
dc.date.available | 2014-12-21T16:51:17Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96477 | - |
dc.description.abstract | The clinical outcomes of 2,054 renal recipients were examined retrospectively based on pre-transplant hepatitis B surface antigen (HBsAg) status to investigate the efficacy of lamivudine treatment in HBsAg positive recipients. Pre-transplant HBsAg positivity was documented in 66 recipients. The 10-year patient and graft survival rates in Ag positive group were significantly lower than those of Ag negative group (64.4/36.6% vs. 88.2/70.5%, respectively, P < 0.0001). Since 1997, lamivudine was used when hepatitis B virus polymerase chain reaction (HBV PCR) was positive or when the level of post-transplant viral load rose. Lamivudine given to 27 recipients markedly improved both 10-year patient and graft survivals compared to Ag positive renal recipients who did not take lamivudine (85.3/59.2% vs. 49.9/22.7%, respectively, P < 0.0001). Overall, 13 viral breakthroughs among 24 lamivudine-responsive patients were observed. The cumulative incidence of viral breakthrough at 60 months was 53.3%. Adefovir rescue in three viral breakthroughs patients induces virological response and restoration of liver function. In 10 patients who did not changed to adefovir, 6 patients are alive with elevated liver enzymes. In conclusion, in the era of lamivudine and adefovir, renal transplantation in HBsAg positive end-stage renal disease patients should not be abandoned | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiviral Agents/therapeutic use* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft Survival* | - |
dc.subject.MESH | Hepatitis B/drug therapy | - |
dc.subject.MESH | Hepatitis B/mortality* | - |
dc.subject.MESH | Hepatitis B/virology | - |
dc.subject.MESH | Hepatitis B Surface Antigens/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation/adverse effects | - |
dc.subject.MESH | Kidney Transplantation/mortality* | - |
dc.subject.MESH | Lamivudine/therapeutic use* | - |
dc.subject.MESH | Liver/pathology | - |
dc.subject.MESH | Liver Function Tests | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Reverse Transcriptase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical outcome of renal transplantation in patients with positive pre-transplant hepatitis B surface antigen | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyung Joon Ahn | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Man Ki Ju | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.1002/jmv.20980 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02273 | - |
dc.contributor.localId | A03949 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J01587 | - |
dc.identifier.eissn | 1096-9071 | - |
dc.identifier.pmid | 17854044 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jmv.20980/abstract | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Joo, Man Ki | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Joo, Man Ki | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 79 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1655 | - |
dc.citation.endPage | 1663 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, Vol.79(11) : 1655-1663, 2007 | - |
dc.identifier.rimsid | 36103 | - |
dc.type.rims | ART | - |
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