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Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

Authors
 Choong-Hwan Lee  ;  Jaemoon Yang  ;  Seungjoo Haam  ;  Yong-Min Huh  ;  Ho-Geun Yoon  ;  Jin-Suck Suh  ;  Yong Jin Song  ;  Eun-Kyung Lim  ;  Sungbaek Seo  ;  Joseph Park 
Citation
 Journal of Materials Chemistry, Vol.17(26) : 2695-2705, 2007 
Journal Title
 Journal of Materials Chemistry 
ISSN
 0959-9428 
Issue Date
2007
Abstract
DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.
Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2007/JM/b702538f#!divAbstract
DOI
10.1039/b702538f
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96470
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