Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer
Authors
Choong-Hwan Lee ; Jaemoon Yang ; Seungjoo Haam ; Yong-Min Huh ; Ho-Geun Yoon ; Jin-Suck Suh ; Yong Jin Song ; Eun-Kyung Lim ; Sungbaek Seo ; Joseph Park
Citation
JOURNAL OF MATERIALS CHEMISTRY , Vol.17(26) : 2695-2705, 2007
DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.