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관절연골세포에서 인테그린과 SMAD 신호경로 사이의 신호교차반응 규명
DC Field | Value | Language |
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dc.contributor.author | 이진우 | - |
dc.contributor.author | 한수봉 | - |
dc.date.accessioned | 2014-12-21T16:49:55Z | - |
dc.date.available | 2014-12-21T16:49:55Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-8933 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96433 | - |
dc.description.abstract | PURPOSE: Identifying the signal cross-talk between integrin signaling cascade and TGF-beta 1 signaling cascade in articular chondrocytes. MATERIALS AND METHODS: To analyze integrin or TGF-beta 1 mediated signaling pathways from extracellular stimuli, type II collagen was coated on the cell culture plate and TGF-beta 1 was added to cell culture media. Chondrocytes were cultured in the conditioned media with each or both stimuli. Altered activation of signaling proteins detected with western blot technique. RESULTS: More rapid attachment of cells was observed in the type II collagen coated group than non-coated group. The phosphorylated SMAD 2 and 3 were expressed in the type II collagen coated group and synergistically up-regulated phosphorylation in the co-treated group. The phosphorylated FAK at tyrosine 925 was activated by TGF-beta 1 treatment and synergistically up-regulated by both stimuli. But there was no meaningfully changed phosphorylation of extracellular signal regulated protein kinase (ERK) 1/2 and p38, as known downstream molecules of FAK cascade. CONCLUSION: This result means that SMAD 2, SMAD 3 and tyrosine 925 of FAK are involved in this signal cross-talking in articular chondrocytes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 65~75 | - |
dc.relation.isPartOf | Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 관절연골세포에서 인테그린과 SMAD 신호경로 사이의 신호교차반응 규명 | - |
dc.title.alternative | Cross-talk between Integrin and SMAD Signal Pathway in Articular Chondrocyte | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | 한수봉 | - |
dc.contributor.googleauthor | 김윤희 | - |
dc.contributor.googleauthor | 박민성 | - |
dc.contributor.googleauthor | 이진우 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03230 | - |
dc.contributor.localId | A04293 | - |
dc.relation.journalcode | J01526 | - |
dc.subject.keyword | Articular chondrocyte | - |
dc.subject.keyword | Signal cross-talk | - |
dc.subject.keyword | Type II collagen | - |
dc.subject.keyword | TGF-β1 | - |
dc.subject.keyword | FAK | - |
dc.subject.keyword | SMAD 2/3 | - |
dc.contributor.alternativeName | Lee, Jin Woo | - |
dc.contributor.alternativeName | Hahn, Soo Bong | - |
dc.contributor.affiliatedAuthor | Lee, Jin Woo | - |
dc.contributor.affiliatedAuthor | Hahn, Soo Bong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 75 | - |
dc.identifier.bibliographicCitation | Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지), Vol.10(2) : 65-75, 2007 | - |
dc.identifier.rimsid | 36076 | - |
dc.type.rims | ART | - |
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