Cited 6 times in
House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권병철 | - |
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김은수 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 신명헌 | - |
dc.date.accessioned | 2014-12-21T16:49:15Z | - |
dc.date.available | 2014-12-21T16:49:15Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96411 | - |
dc.description.abstract | The house dust mite (HDM) is considered to be the most common indoor allergen associated with bronchial asthma. In this study, we investigated whether crude extract of the HDM Dermatophagoides farinae could activate human eosinophilic leukemic cells (EoL-1) to induce upregulation of cell-surface adhesion molecules. When EoL-1 cells were incubated with D. farinae extract, expression of intercellular adhesion molecule-1 (ICAM-1) significantly increased on the cell surfaces compared to cells incubated with medium alone. In contrast, surface expression of CD11b and CD49d in EoL-1 cells was not affected by D. farinae extract. In addition, pretreatment of cells with NF-κB inhibitor (MG-132) or JNK inhibitor (SP600125) significantly inhibited ICAM-1 expression promoted by HDM extract. However, neither p38 MAP kinase inhibitor nor MEK inhibitor prevented HDM-induced ICAM-1 expression in EoL-1 cells. These results suggest that crude extract of D. farinae induces ICAM-1 expression in EoL-1 cells through signaling pathways involving both NF-κB and JNK. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 815~819 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Byoung Chul Kwon | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Myeong Heon Shin | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.contributor.googleauthor | Eun Soo Kim | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.identifier.doi | 10.3346/jkms.2007.22.5.815 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00219 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A02099 | - |
dc.contributor.localId | A00805 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.contributor.alternativeName | Kwon, Byoung Chul | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Eun Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | Kwon, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 815 | - |
dc.citation.endPage | 819 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.22(8) : 815-819, 2007 | - |
dc.identifier.rimsid | 37516 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.