Cited 33 times in
Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2014-12-21T16:49:01Z | - |
dc.date.available | 2014-12-21T16:49:01Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96404 | - |
dc.description.abstract | Claudin-7 has recently been suggested to be a distal nephron marker. We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron. We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas. In addition, the methylation specific-PCR (MSP) of claudin-7 was performed. Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively. The sensitivity and specificity of claudin-7 in diagnosing chromophobe RCC among subtypes of RCC were 95.0% and 92.3%. Those of parvalbumin were 80.0% and 88.9%. The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma. All of the cases examined in the MSP revealed the presence of unmethylated promoter of claudin-7 without regard to claudin-7 immunoreactivity. Hypermethylation of the promoter might not be the underlying mechanism for loss of its expression in RCC. Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 305~310 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Yoo Duk Choi | - |
dc.contributor.googleauthor | Ki Seung Kim | - |
dc.contributor.googleauthor | Chan Choi | - |
dc.contributor.googleauthor | Sang Woo Juhng | - |
dc.contributor.googleauthor | Jae Y Ro | - |
dc.contributor.googleauthor | Ja June Jang | - |
dc.contributor.googleauthor | Seo Hee Rha | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Youngkyu Park | - |
dc.contributor.googleauthor | Sunhyo Ryu | - |
dc.identifier.doi | 10.3346/jkms.2007.22.2.305 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 310 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.22(2) : 305-310, 2007 | - |
dc.identifier.rimsid | 37511 | - |
dc.type.rims | ART | - |
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