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다기관, 공개 임상, 단일군 시험을 통한 난치성 부분 간질을 가진 한국인에서 부가요법으로 사용된 레비티라세탐의유효성 및 안전성: 1년 이상의 추적
DC Field | Value | Language |
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dc.contributor.author | 허경 | - |
dc.date.accessioned | 2014-12-21T16:48:38Z | - |
dc.date.available | 2014-12-21T16:48:38Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 2234-5531 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96391 | - |
dc.description.abstract | Purpose: This prospective, open-label study evaluated the efficacy and safety of adjunctive levetiracetam (LEV) in Korean adults with uncontrolled partial epilepsy. Methods: A total of 100 patients whose partial seizures were inadequately controlled on their current antiepileptic drugs were enrolled and received LEV (1000-3000 mg/day). Seizure count and adverse events (AEs) were recorded by patients. Global evaluation scale (GES) and quality of life (QOLIE-31) were also evaluated. Additionally effectiveness over 1-year follow-up was investigated. Results: Ninety-two patients completed the short-term 16-week trial. The median percent reduction in weekly seizure frequency over the treatment period was 43.2%. The ≥50% and ≥75% responder rates were 45.4% and 36.1%, respectively. Seizure freedom was observed in 17 patients throughout the initial 16-week treatment period. On investigator’s GES, 81 patients were considered improved, with 41 patients showing marked improvement. Most QOLIE-31 scales improved significantly. At the end of the trial, 79 chose to continue follow-up treatment with LEV. At the follow-up visit (ranging 60 to 81 weeks), 64 patients were still taking LEV; during the last 16 weeks, 65.6% of patients had ≥50% reduction, 50.0% had ≥75% reduction, and 35.9% had a 100% reduction. Seven patients showed continuous seizure freedom from the initiation of LEV treatment. During the entire treatment period, LEV was withdrawn in 36 patients; due to lack of efficacy in 22, AEs in six, both in three, other reasons in five. Conclusion: Adjunctive LEV therapy in patients with refractory partial epilepsy was effective and well-tolerated, as evidenced by the high seizure freedom and retention rates in both the short-term trial and the long-term follow-up. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 25~32 | - |
dc.relation.isPartOf | Journal of Korean Epilepsy Society (대한간질학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 다기관, 공개 임상, 단일군 시험을 통한 난치성 부분 간질을 가진 한국인에서 부가요법으로 사용된 레비티라세탐의유효성 및 안전성: 1년 이상의 추적 | - |
dc.title.alternative | Efficacy and Safety of Levetiracetam as Adjunctive Treatment in a Multicenter Open-Label Single-Arm Trial in Korean Patients with Refractory Partial Epilepsy : Over 1-Year Follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | 허경 | - |
dc.contributor.googleauthor | 이상암 | - |
dc.contributor.googleauthor | 이병인 | - |
dc.contributor.googleauthor | 송홍기 | - |
dc.contributor.googleauthor | 이상도 | - |
dc.contributor.googleauthor | 이상건 | - |
dc.contributor.googleauthor | 김재문 | - |
dc.contributor.googleauthor | 김정연 | - |
dc.contributor.googleauthor | 신동진 | - |
dc.contributor.googleauthor | 허균 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04341 | - |
dc.relation.journalcode | J01509 | - |
dc.contributor.alternativeName | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Heo, Kyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 32 | - |
dc.identifier.bibliographicCitation | Journal of Korean Epilepsy Society (대한간질학회지), Vol.11(1) : 25-32, 2007 | - |
dc.identifier.rimsid | 37499 | - |
dc.type.rims | ART | - |
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