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The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients

DC Field Value Language
dc.contributor.author최동훈-
dc.contributor.author고영국-
dc.contributor.author김진배-
dc.contributor.author박성하-
dc.contributor.author심지영-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.date.accessioned2014-12-21T16:47:08Z-
dc.date.available2014-12-21T16:47:08Z-
dc.date.issued2007-
dc.identifier.issn0263-6352-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96346-
dc.description.abstractOBJECTIVE: The aldosterone-renin ratio (ARR) is widely used to screen for primary aldosteronism, and may reflect a relative excess of aldosterone secretion compared with renin secretion. Excess aldosterone may have a detrimental effect on vascular stiffness. We therefore hypothesized that ARR and aldosterone are independently correlated with pulse wave velocity (PWV) in hypertensive patients. METHODS: The study consisted of 438 hypertensive patients. Serum aldosterone and plasma renin activity were measured in a sitting position using standard techniques. The PWV was determined by measuring the heart to femoral PWV (hfPWV) and brachial to ankle PWV with a VP-2000 pulse wave unit. RESULTS: Group 1 was defined as patients with ARR of at least 20 (n = 53) with serum aldosterone >or= 12 ng/dl, while the remainder comprised group 2. Comparisons between the two groups reveal group 1 tended to have higher age, significantly higher proportion of women and higher systolic/diastolic blood pressure. Patients in group 1 also had a significantly higher index of central arterial stiffness (hfPWV 1048 +/- 202 vs 978 +/- 182, P = 0.010) compared with group 2. Multiple linear regression revealed that aldosterone, but not the ARR, is significantly associated with hfPWV but not brachial to ankle PWV, after controlling for age, systolic blood pressure and heart rate at the time of PWV measurement, body mass index, gender, low-density lipoprotein-cholesterol, triglyceride, high-density lipoprotein-cholesterol, blood pressure medication and statins. CONCLUSIONS: Serum aldosterone is significantly associated with central aortic PWV in hypertensive patients. The results demonstrate a possible role for aldosterone in developing central aortic stiffness and increased PWV in hypertensive patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1279~1283-
dc.relation.isPartOfJOURNAL OF HYPERTENSION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorJin-Bae Kim-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorChi Young Shim-
dc.identifier.doi10.1097/HJH.0b013e3280f31b6e-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04053-
dc.contributor.localIdA00127-
dc.contributor.localIdA01016-
dc.contributor.localIdA01512-
dc.contributor.localIdA02213-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.relation.journalcodeJ01448-
dc.identifier.eissn1473-5598-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004872-200706000-00016&LSLINK=80&D=ovft-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Jin Bae-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameShim, Chi Young-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Jin Bae-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorShim, Chi Young-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.rights.accessRightsnot free-
dc.citation.volume25-
dc.citation.number6-
dc.citation.startPage1279-
dc.citation.endPage1283-
dc.identifier.bibliographicCitationJOURNAL OF HYPERTENSION, Vol.25(6) : 1279-1283, 2007-
dc.identifier.rimsid37027-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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