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CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

DC Field Value Language
dc.contributor.author김형표-
dc.date.accessioned2014-12-21T16:46:45Z-
dc.date.available2014-12-21T16:46:45Z-
dc.date.issued2007-
dc.identifier.issn0022-1007-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96334-
dc.description.abstractRegulatory T cells (T reg cells) are a population of CD4+ T cells that limit immune responses. FoxP3 is a master control transcription factor for development and function of these cells, but its regulation is poorly understood. We have identified a T cell receptor-responsive enhancer in the FoxP3 first intron that is dependent on a cyclic-AMP response element binding protein (CREB)/activating transcription factor (ATF) site overlapping a CpG island. Methylation of this island inversely correlates with CREB binding and FoxP3 expression. Interestingly, transforming growth factor-beta, which induces T reg cell formation, decreases methylation of the CpG island and increases FoxP3 expression. Similarly, inhibiting methylation with 5-azacytidine or knocking down the DNA methyltransferase Dnmt1 also induces FoxP3 expression. Conversely, methylation of the CpG island, which decreases CREB binding or expression of dominant-negative CREB, decreases FoxP3 gene expression. Thus, T cell receptor-induced FoxP3 expression in T reg cells is controlled both by sequence-specific binding of CREB/ATF and by DNA methylation of a CpG island.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1543~1551-
dc.relation.isPartOfJOURNAL OF EXPERIMENTAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Environmental Medical Biology (환경의생물학)-
dc.contributor.googleauthorHyoung-Pyo Kim-
dc.contributor.googleauthorWarren J. Leonard-
dc.identifier.doi10.1084/jem.20070109-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01163-
dc.relation.journalcodeJ01409-
dc.identifier.eissn1540-9538-
dc.contributor.alternativeNameKim, Hyoung Pyo-
dc.contributor.affiliatedAuthorKim, Hyoung Pyo-
dc.rights.accessRightsfree-
dc.citation.volume204-
dc.citation.number7-
dc.citation.startPage1543-
dc.citation.endPage1551-
dc.identifier.bibliographicCitationJOURNAL OF EXPERIMENTAL MEDICINE, Vol.204(7) : 1543-1551, 2007-
dc.identifier.rimsid37019-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers

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