Cited 85 times in

CXCL5 overexpression is associated with late stage gastric cancer

DC Field Value Language
dc.contributor.author방승민-
dc.contributor.author송시영-
dc.contributor.author김명화-
dc.contributor.author박정엽-
dc.date.accessioned2014-12-21T16:43:52Z-
dc.date.available2014-12-21T16:43:52Z-
dc.date.issued2007-
dc.identifier.issn0171-5216-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96245-
dc.description.abstractPURPOSE: Chemokines play multiple roles in the development and progression of many different tumors. Our cDNA array data suggested that chemokine CXCL5 was upregulated in gastric cancer. Here, we analyzed CXCL5 protein expression in gastric cancer and investigated the clinical implications of CXCL5 upregulation. METHODS: Immunostaining for CXCL5 was performed on gastric tissue microarrays of tissue specimens obtained by gastrectomy. The intensity of immunostaining in tumor tissue was considered strong when tumor tissue staining was more intense than in normal tissue; the intensity was null when staining was weaker in the tumor than in normal tissue; and the intensity was weak when staining was similar in both tissues. Serum CXCL5 levels and microvascular density in tumor tissue were measured by ELISA and monoclonal antibody to Factor VIII. RESULTS: Strong CXCL5 expression correlated with tumor stage. CXCL5 expression did not correlate with T stage. However, N stage positively correlated with CXCL5 expression. Serum CXCL5 levels in late stage (IIIB, IV) gastric cancer patients were higher than in patients with benign conditions. Microvascular density was higher in tumors with strong CXCL5 expression, but the correlation with CXCL5 was not linear. Multiple logistic regression analyses showed that, compared to no or weak expression, strong expression of CXCL5 was a significant risk factor for high N stage (N2, N3). CONCLUSIONS: CXCL5 overexpression was associated with late stage gastric cancer and high N stage. These results suggest a role for CXCL5 in the progression of gastric cancer, specifically in lymph node metastasis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent835~840-
dc.relation.isPartOfJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHCarcinoma, Signet Ring Cell/metabolism-
dc.subject.MESHCarcinoma, Signet Ring Cell/pathology-
dc.subject.MESHChemokine CXCL5/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy-
dc.subject.MESHGastric Mucosa/metabolism-
dc.subject.MESHGastric Mucosa/pathology-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHStomach Neoplasms/metabolism*-
dc.subject.MESHStomach Neoplasms/pathology-
dc.titleCXCL5 overexpression is associated with late stage gastric cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorKyung Hwa Park-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorSang Seok Koh-
dc.contributor.googleauthorJingu Gang-
dc.contributor.googleauthorJi-Eun Lee-
dc.contributor.googleauthorMyoung Hwan Kim-
dc.contributor.googleauthorSeungmin Bang-
dc.identifier.doi10.1007/s00432-007-0225-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01786-
dc.contributor.localIdA02035-
dc.contributor.localIdA00430-
dc.contributor.localIdA01647-
dc.relation.journalcodeJ01283-
dc.identifier.eissn1432-1335-
dc.identifier.pmid17479287-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00432-007-0225-x-
dc.subject.keywordChemokine-
dc.subject.keywordCXCL5-
dc.subject.keywordGastric cancer-
dc.subject.keywordLymph node metastasis-
dc.contributor.alternativeNameBang, Seung Min-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameKim, Myung Hwa-
dc.contributor.alternativeNamePark, Jeong Youp-
dc.contributor.affiliatedAuthorBang, Seung Min-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorKim, Myung Hwa-
dc.contributor.affiliatedAuthorPark, Jeong Youp-
dc.rights.accessRightsnot free-
dc.citation.volume133-
dc.citation.number11-
dc.citation.startPage835-
dc.citation.endPage840-
dc.identifier.bibliographicCitationJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.133(11) : 835-840, 2007-
dc.identifier.rimsid35004-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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