Cited 116 times in
Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.date.accessioned | 2014-12-21T16:42:19Z | - |
dc.date.available | 2014-12-21T16:42:19Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96194 | - |
dc.description.abstract | PURPOSE: To compare the dose-volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. METHODS AND MATERIALS: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB-IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRU(RP)) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (alpha/beta = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. RESULTS: The mean values of the DVH parameters and ICRU(RP) were significantly greater in patients with a score of > or =2 than in those with a score <2 at 12 months after RT (ICRU(RP), 71 Gy(alpha/beta3) vs. 66 Gy(alpha/beta3), p = 0.02; D(0.1cc), 93 Gy(alpha/beta3) vs. 85 Gy(alpha/beta3), p = 0.04; D(1cc), 80 Gy(alpha/beta3) vs. 73 Gy(alpha/beta3), p = 0.02; D(2cc), 75 Gy(alpha/beta3) vs. 69 Gy(alpha/beta3), p = 0.02). The probability of a score of > or =2 showed a significant relationship with the DVH parameters and ICRU(RP) (ICRU(RP), p = 0.03; D(0.1cc), p = 0.05; D(1cc), p = 0.02; D(2cc), p = 0.02). CONCLUSION: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score > or =2 rectosigmoid mucosal changes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1446~1454 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/radiotherapy | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brachytherapy/methods* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/radiotherapy | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Dose-Response Relationship, Radiation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intestinal Mucosa/pathology | - |
dc.subject.MESH | Intestinal Mucosa/radiation effects* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Radiation Injuries/pathology* | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy Planning, Computer-Assisted/methods* | - |
dc.subject.MESH | Rectum/pathology | - |
dc.subject.MESH | Rectum/radiation effects* | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Sigmoidoscopy | - |
dc.subject.MESH | Tumor Burden | - |
dc.subject.MESH | Uterine Cervical Neoplasms/radiotherapy* | - |
dc.title | Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Dae Kyung Sohn | - |
dc.contributor.googleauthor | Kwan Ho Cho | - |
dc.contributor.googleauthor | Sung Yong Park | - |
dc.contributor.googleauthor | Dongho Shin | - |
dc.contributor.googleauthor | Myonggeun Yoon | - |
dc.contributor.googleauthor | Dae Yong Kim | - |
dc.contributor.googleauthor | Sang Min Yoon | - |
dc.contributor.googleauthor | Kyung Hwan Shin | - |
dc.contributor.googleauthor | Jong Won Kim | - |
dc.contributor.googleauthor | Joo-Young Kim | - |
dc.identifier.doi | 10.1016/j.ijrobp.2007.02.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00273 | - |
dc.relation.journalcode | J01157 | - |
dc.identifier.eissn | 1879-355X | - |
dc.identifier.pmid | 17482766 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0360301607003112 | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 68 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1446 | - |
dc.citation.endPage | 1454 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Vol.68(5) : 1446-1454, 2007 | - |
dc.identifier.rimsid | 34965 | - |
dc.type.rims | ART | - |
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