Cited 32 times in
Association between susceptibility to advanced stage endometriosis and the genetic polymorphisms of aryl hydrocarbon receptor repressor and glutathione-S-transferase T1 genes
DC Field | Value | Language |
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dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2014-12-21T16:39:27Z | - |
dc.date.available | 2014-12-21T16:39:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0268-1161 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96102 | - |
dc.description.abstract | BACKGROUND: This study was performed to determine whether genetic polymorphisms of aryl hydrocarbon receptor repressor (AhRR), glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) are associated with susceptibility to advanced stage endometriosis in a Korean population. METHODS: This study comprised 316 women with advanced stage endometriosis and 256 control women without endometriosis. Genotyping of the AhRR codon 185 was performed by real-time polymerase chain reaction (PCR) analysis. GSTM1 and GSTT1 genotyping for gene deletions were carried out by multiplex PCR analysis. RESULTS: G allele frequency at codon 185 of AhRR was increased in patients with endometriosis (P=0.047), and there was a trend for an association of C/G+G/G genotypes with risk of endometriosis (P=0.06). The proportion of null mutation at GSTT1 also tended to increase (P=0.06) in patients with endometriosis, whereas there was no difference in the genotype distribution of GSTM1 genes. Analyzing AhRR and GSTT1 together, we found that patients with high-risk genotypes at both loci have increased risk of endometriosis, compared with patients without high-risk genotypes (P=0.015). CONCLUSIONS: These findings suggest that the AhRR codon 185 and GSTT1 polymorphisms are associated with the risk of advanced stage endometriosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1866~1870 | - |
dc.relation.isPartOf | HUMAN REPRODUCTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Basic Helix-Loop-Helix Transcription Factors | - |
dc.subject.MESH | Codon | - |
dc.subject.MESH | Endometriosis/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glutathione Transferase/genetics* | - |
dc.subject.MESH | Homozygote | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Repressor Proteins/genetics* | - |
dc.title | Association between susceptibility to advanced stage endometriosis and the genetic polymorphisms of aryl hydrocarbon receptor repressor and glutathione-S-transferase T1 genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Sung Hoon Kim | - |
dc.contributor.googleauthor | Young Min Choi | - |
dc.contributor.googleauthor | Shin Yong Moon | - |
dc.contributor.googleauthor | Jung Gu Kim | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.contributor.googleauthor | Kyu Sup Lee | - |
dc.contributor.googleauthor | Min A. Hong | - |
dc.contributor.googleauthor | Gyoung Hoon Lee | - |
dc.identifier.doi | 10.1093/humrep/dem112 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J01013 | - |
dc.identifier.eissn | 1460-2350 | - |
dc.identifier.pmid | 17513317 | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1866 | - |
dc.citation.endPage | 1870 | - |
dc.identifier.bibliographicCitation | HUMAN REPRODUCTION, Vol.22(7) : 1866-1870, 2007 | - |
dc.identifier.rimsid | 35433 | - |
dc.type.rims | ART | - |
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