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Radiation-induced hepatic toxicity after radiotherapy combined with chemotherapy for hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author성진실-
dc.contributor.author심수정-
dc.contributor.author안상훈-
dc.contributor.author이익재-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.date.accessioned2014-12-21T16:39:09Z-
dc.date.available2014-12-21T16:39:09Z-
dc.date.issued2007-
dc.identifier.issn1386-6346-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96092-
dc.description.abstractAim: The purpose of the present study was to analyze hepatic toxicity following radiotherapy combined with regional chemotherapy for hepatocellular carcinoma (HCC). Methods: From 2001 to 2003, a total of 132 patients with HCC received 3-D conformal radiation therapy (3D-CRT) combined with chemotherapy. Patients were divided into two groups based on drug localization: the transcatheter arterial chemoembolization (TACE) group, where the chemotherapeutic drug (adriamycin) was localized within the tumor, and the non-TACE group, where the drugs (adriamycin, cisplatin, 5-fluorouracil) were diffusely spread over the entire liver. Results: Patients were evaluated by biochemical parameters for any hepatic toxicity prior to, during, and until 12 months after 3D-CRT. Hepatic toxicity was defined as radiation-induced liver disease (RILD) or combined modality-induced liver disease (CMILD), which is defined as RILD with abnormal elevation of total bilirubin levels. In the TACE group, three patients developed RILD (5.6%) and none developed CMILD. In the non-TACE group, three patients (3.7%) and seven patients (8.8%) developed RILD and CMILD, respectively. Conclusion: Hepatic toxicity following radiotherapy combined with regional chemotherapy for HCC might be influenced by the distribution of the chemotherapeutic drugs. A more precise understanding of hepatic toxicity from chemoradiotherapy will help design optimal treatments for HCC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent906~913-
dc.relation.isPartOfHEPATOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRadiation-induced hepatic toxicity after radiotherapy combined with chemotherapy for hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorSu J. Shim-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorSang H. Ahn-
dc.contributor.googleauthorChae Y. Chon-
dc.contributor.googleauthorKwang H. Han-
dc.contributor.googleauthorIk J. Lee-
dc.identifier.doi10.1111/j.1872-034X.2007.00149.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01956-
dc.contributor.localIdA02195-
dc.contributor.localIdA02226-
dc.contributor.localIdA03055-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.relation.journalcodeJ00987-
dc.identifier.eissn1872-034X-
dc.identifier.pmid17610506-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1872-034X.2007.00149.x/abstract-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameShim, Su Jung-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorShim, Su Jung-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.rights.accessRightsnot free-
dc.citation.volume37-
dc.citation.number11-
dc.citation.startPage906-
dc.citation.endPage913-
dc.identifier.bibliographicCitationHEPATOLOGY RESEARCH, Vol.37(11) : 906-913, 2007-
dc.identifier.rimsid35427-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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